{"brand":"Compound Laws","url":"https://compoundlaws.com/compounds/endomorphin-1/","compound":{"slug":"endomorphin_1","name":"Endomorphin-1","category":"peptide","framework":"csa_scheduling","description":"Endogenous opioid tetrapeptide (Tyr-Pro-Trp-Phe-NH2) with high mu-opioid affinity. Unscheduled in all 51 US jurisdictions - an opioid peptide with no structural similarity to any scheduled small-molecule opioid, so no state analogue act reaches it on the RUO path. Binding constraint is FEDERAL and use-dependent: unapproved new drug under FD&C 21 USC 355 for any consumer/human-use marketing, and the Analogue Act human-consumption hinge (SC/NE closest calls). RUO ONLY.","same_as":"https://en.wikipedia.org/wiki/Endomorphin"},"as_of":"2026-10-22","summary":"Endomorphin-1 is legal to sell at retail in 51 states, restricted in 0, in a gray area in 0 and illegal in 0. Federal: not federally scheduled. Verified through October 22, 2026.","forms":[{"form":"all","label":"All forms","counts":{"legal":51,"restricted":0,"gray":0,"illegal":0,"unknown":0},"federal":{"status":"legal","headline":"Endomorphin-1 - not federally scheduled; endogenous opioid tetrapeptide, no CSA entry and no analogue-act structural hook"},"states":[{"code":"AL","name":"Alabama","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/alabama/"},{"code":"AK","name":"Alaska","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/alaska/"},{"code":"AZ","name":"Arizona","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/arizona/"},{"code":"AR","name":"Arkansas","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/arkansas/"},{"code":"CA","name":"California","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/california/"},{"code":"CO","name":"Colorado","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/colorado/"},{"code":"CT","name":"Connecticut","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/connecticut/"},{"code":"DE","name":"Delaware","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/delaware/"},{"code":"DC","name":"District of Columbia","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/district-of-columbia/"},{"code":"FL","name":"Florida","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-10-07","url":"https://compoundlaws.com/compounds/endomorphin-1/florida/"},{"code":"GA","name":"Georgia","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/georgia/"},{"code":"HI","name":"Hawaii","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/hawaii/"},{"code":"ID","name":"Idaho","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/idaho/"},{"code":"IL","name":"Illinois","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/illinois/"},{"code":"IN","name":"Indiana","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/indiana/"},{"code":"IA","name":"Iowa","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/iowa/"},{"code":"KS","name":"Kansas","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-09-23","url":"https://compoundlaws.com/compounds/endomorphin-1/kansas/"},{"code":"KY","name":"Kentucky","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/kentucky/"},{"code":"LA","name":"Louisiana","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/louisiana/"},{"code":"ME","name":"Maine","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/maine/"},{"code":"MD","name":"Maryland","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/maryland/"},{"code":"MA","name":"Massachusetts","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/massachusetts/"},{"code":"MI","name":"Michigan","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/michigan/"},{"code":"MN","name":"Minnesota","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-10-22","url":"https://compoundlaws.com/compounds/endomorphin-1/minnesota/"},{"code":"MS","name":"Mississippi","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/mississippi/"},{"code":"MO","name":"Missouri","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/missouri/"},{"code":"MT","name":"Montana","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/montana/"},{"code":"NE","name":"Nebraska","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled; analog effect-prong includes 'analgesic' - human-consumption scheduling gate blocks reach (low-moderate)","verified_at":"2026-09-23","url":"https://compoundlaws.com/compounds/endomorphin-1/nebraska/"},{"code":"NV","name":"Nevada","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/nevada/"},{"code":"NH","name":"New Hampshire","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-10-07","url":"https://compoundlaws.com/compounds/endomorphin-1/new-hampshire/"},{"code":"NJ","name":"New Jersey","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/new-jersey/"},{"code":"NM","name":"New Mexico","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/new-mexico/"},{"code":"NY","name":"New York","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/new-york/"},{"code":"NC","name":"North Carolina","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/north-carolina/"},{"code":"ND","name":"North Dakota","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/north-dakota/"},{"code":"OH","name":"Ohio","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/ohio/"},{"code":"OK","name":"Oklahoma","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/oklahoma/"},{"code":"OR","name":"Oregon","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/oregon/"},{"code":"PA","name":"Pennsylvania","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/pennsylvania/"},{"code":"RI","name":"Rhode Island","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-10-19","url":"https://compoundlaws.com/compounds/endomorphin-1/rhode-island/"},{"code":"SC","name":"South Carolina","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled; analog effect-prong reaches analgesics - human-consumption gate is the SOLE barrier (moderate residual risk)","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/south-carolina/"},{"code":"SD","name":"South Dakota","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled; HAS an analog statute (treated as Sch I) but does not reach EM-1 - corrected from earlier 'no statute' note","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/south-dakota/"},{"code":"TN","name":"Tennessee","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/tennessee/"},{"code":"TX","name":"Texas","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/texas/"},{"code":"UT","name":"Utah","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-10-07","url":"https://compoundlaws.com/compounds/endomorphin-1/utah/"},{"code":"VT","name":"Vermont","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/vermont/"},{"code":"VA","name":"Virginia","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-09-23","url":"https://compoundlaws.com/compounds/endomorphin-1/virginia/"},{"code":"WA","name":"Washington","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/washington/"},{"code":"WV","name":"West Virginia","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/west-virginia/"},{"code":"WI","name":"Wisconsin","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/wisconsin/"},{"code":"WY","name":"Wyoming","status":"legal","state_status":null,"federal_overlay":false,"headline":"Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide","verified_at":"2026-07-18","url":"https://compoundlaws.com/compounds/endomorphin-1/wyoming/"}]}],"deadlines":[],"recent_changes":[]}