7-OH (7-Hydroxymitragynine): Federal Status (2026)

Instrument

Temporary placement of mitragynine pseudoindoxyl, MGM-15 and MGM-16 in Schedule I - amendatory text

Source

https://www.federalregister.gov/documents/2026/08/26/2026-17429/schedules-of-controlled-substances-temporary-placement-of-mitragynine-pseudoindoxyl-mgm-15-and

Retrieved

2026-09-22

Fingerprint

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For the reasons set out above, DEA amends 21 CFR part 1308 as 
follows:
PART 1308--SCHEDULES OF CONTROLLED SUBSTANCES
0
1. The authority citation for part 1308 continues to read as follows:
 Authority: 21 U.S.C. 811, 812, 871(b), 956(b), unless otherwise 
noted.
0
2. In Sec. 1308.11, add paragraphs (h)(89) through (91) to read as 
follows:
Sec. 1308.11 Schedule I.
* * * * *
 (h) * * *
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 * * * * * * *
(89) Methyl (E)-2-((1'S,6'S,7'S)-6'-ethyl-4-methoxy-3-oxo- 9672
 3',5',6',7',8',8a'-hexahydro-2'H-spiro[indoline-2,1'-
 indolizine]-7'-yl)-3-methoxyacrylate (commonly known as
 mitragynine pseudoindoxyl) including its isomers, esters,
 ethers, salts, and salts of isomers, esters, and ethers,
 whenever the existence of such isomers, esters, ethers, and
 salts is possible. Since nomenclature of this substance is not
 internationally standardized, compounds of this structure,
 regardless of numerical designation of atomic positions are
 covered
(90) Methyl (E)-2-((2S,3S,7aS,12aR,12bS)-3-ethyl-7a-hydroxy-8- 9673
 methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo[2,3-
 a]quinolizin-2-yl)-3-methoxyacrylate (commonly known as MGM-
 15; also known as dihydro-7-hydroxymitragynine) including its
 isomers, esters, ethers, salts, and salts of isomers, esters,
 and ethers, whenever the existence of such isomers, esters,
 ethers, and salts is possible. Since nomenclature of this
 substance is not internationally standardized, compounds of
 this structure, regardless of numerical designation of atomic
 positions are covered
(91) Methyl (E)-2-((2S,3S,7aS,12aR,12bS)-3-ethyl-9-fluoro-7a- 9674
 hydroxy-8- methoxy-1,2,3,4,6,7,7a,12,12a,12b-
 decahydroindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate
 (commonly known as MGM-16; also known as 9-fluoro-dihydro-7-
 hydroxymitragynine; or 10-fluoro-dihydro-7-hydroxymitragynine
 (depending on numbering convention)) including its isomers,
 esters, ethers, salts, and salts of isomers, esters, and
 ethers, whenever the existence of such isomers, esters,
 ethers, and salts is possible. Since nomenclature of this
 substance is not internationally standardized, compounds of
 this structure, regardless of numerical designation of atomic
 positions are covered
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