9-OH (9-hydroxycorynantheidine): Federal Status (2026)

Instrument

Temporary placement of mitragynine pseudoindoxyl, MGM-15 and MGM-16 in Schedule I - amendatory text

Source

https://www.federalregister.gov/documents/2026/08/26/2026-17429/schedules-of-controlled-substances-temporary-placement-of-mitragynine-pseudoindoxyl-mgm-15-and

Retrieved

2026-09-22

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fa16cebdc1144cd6

For the reasons set out above, DEA amends 21 CFR part 1308 as 
follows:
PART 1308--SCHEDULES OF CONTROLLED SUBSTANCES
0
1. The authority citation for part 1308 continues to read as follows:
 Authority: 21 U.S.C. 811, 812, 871(b), 956(b), unless otherwise 
noted.
0
2. In Sec. 1308.11, add paragraphs (h)(89) through (91) to read as 
follows:
Sec. 1308.11 Schedule I.
* * * * *
 (h) * * *
------------------------------------------------------------------------
 * * * * * * *
(89) Methyl (E)-2-((1'S,6'S,7'S)-6'-ethyl-4-methoxy-3-oxo- 9672
 3',5',6',7',8',8a'-hexahydro-2'H-spiro[indoline-2,1'-
 indolizine]-7'-yl)-3-methoxyacrylate (commonly known as
 mitragynine pseudoindoxyl) including its isomers, esters,
 ethers, salts, and salts of isomers, esters, and ethers,
 whenever the existence of such isomers, esters, ethers, and
 salts is possible. Since nomenclature of this substance is not
 internationally standardized, compounds of this structure,
 regardless of numerical designation of atomic positions are
 covered
(90) Methyl (E)-2-((2S,3S,7aS,12aR,12bS)-3-ethyl-7a-hydroxy-8- 9673
 methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo[2,3-
 a]quinolizin-2-yl)-3-methoxyacrylate (commonly known as MGM-
 15; also known as dihydro-7-hydroxymitragynine) including its
 isomers, esters, ethers, salts, and salts of isomers, esters,
 and ethers, whenever the existence of such isomers, esters,
 ethers, and salts is possible. Since nomenclature of this
 substance is not internationally standardized, compounds of
 this structure, regardless of numerical designation of atomic
 positions are covered
(91) Methyl (E)-2-((2S,3S,7aS,12aR,12bS)-3-ethyl-9-fluoro-7a- 9674
 hydroxy-8- methoxy-1,2,3,4,6,7,7a,12,12a,12b-
 decahydroindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate
 (commonly known as MGM-16; also known as 9-fluoro-dihydro-7-
 hydroxymitragynine; or 10-fluoro-dihydro-7-hydroxymitragynine
 (depending on numbering convention)) including its isomers,
 esters, ethers, salts, and salts of isomers, esters, and
 ethers, whenever the existence of such isomers, esters,
 ethers, and salts is possible. Since nomenclature of this
 substance is not internationally standardized, compounds of
 this structure, regardless of numerical designation of atomic
 positions are covered
------------------------------------------------------------------------

Instrument

Schedule I temporary listing, MGM-15 (dihydro-7-hydroxymitragynine) (drug code 9673), amendatory text of FR Doc. 2026-17429

Source

https://www.federalregister.gov/documents/full_text/text/2026/08/26/2026-17429.txt

Retrieved

2026-10-28

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753842c4cd890452

(90) Methyl (E)-2-((2S,3S,7aS,12aR,12bS)-3-ethyl-7a-hydroxy-8-      9673
 methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo[2,3-
 a]quinolizin-2-yl)-3-methoxyacrylate (commonly known as MGM-
 15; also known as dihydro-7-hydroxymitragynine) including its
 isomers, esters, ethers, salts, and salts of isomers, esters,
 and ethers, whenever the existence of such isomers, esters,
 ethers, and salts is possible. Since nomenclature of this
 substance is not internationally standardized, compounds of
 this structure, regardless of numerical designation of atomic
 positions are covered

Instrument

Schedule I temporary listing, MGM-16 (9-fluoro-dihydro-7-hydroxymitragynine; 10-fluoro under an alternate numbering) (drug code 9674), amendatory text of FR Doc. 2026-17429

Source

https://www.federalregister.gov/documents/full_text/text/2026/08/26/2026-17429.txt

Retrieved

2026-10-28

Fingerprint

78d1ca95da6494c6

(91) Methyl (E)-2-((2S,3S,7aS,12aR,12bS)-3-ethyl-9-fluoro-7a-       9674
 hydroxy-8- methoxy-1,2,3,4,6,7,7a,12,12a,12b-
 decahydroindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate
 (commonly known as MGM-16; also known as 9-fluoro-dihydro-7-
 hydroxymitragynine; or 10-fluoro-dihydro-7-hydroxymitragynine
 (depending on numbering convention)) including its isomers,
 esters, ethers, salts, and salts of isomers, esters, and
 ethers, whenever the existence of such isomers, esters,
 ethers, and salts is possible. Since nomenclature of this
 substance is not internationally standardized, compounds of
 this structure, regardless of numerical designation of atomic
 positions are covered

Instrument

Controlled substance analogue (definition and treatment)

Source

https://www.govinfo.gov/content/pkg/USCODE-2023-title21/html/USCODE-2023-title21-chap13-subchapI-partA-sec802.htm

Retrieved

2026-11-08

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4d9abc695447adae

(32)(A) Except as provided in subparagraph (C), the term "controlled substance analogue" means a substance—

(i) the chemical structure of which is substantially similar to the chemical structure of a controlled substance in schedule I or II;

(ii) which has a stimulant, depressant, or hallucinogenic effect on the central nervous system that is substantially similar to or greater than the stimulant, depressant, or hallucinogenic effect on the central nervous system of a controlled substance in schedule I or II; or

(iii) with respect to a particular person, which such person represents or intends to have a stimulant, depressant, or hallucinogenic effect on the central nervous system that is substantially similar to or greater than the stimulant, depressant, or hallucinogenic effect on the central nervous system of a controlled substance in schedule I or II.

(B) The designation of gamma butyrolactone or any other chemical as a listed chemical pursuant to paragraph (34) or (35) does not preclude a finding pursuant to subparagraph (A) of this paragraph that the chemical is a controlled substance analogue.

(C) Such term does not include—

(i) a controlled substance;

(ii) any substance for which there is an approved new drug application;

(iii) with respect to a particular person any substance, if an exemption is in effect for investigational use, for that person, under section 355 of this title to the extent conduct with respect to such substance is pursuant to such exemption; or

(iv) any substance to the extent not intended for human consumption before such an exemption takes effect with respect to that substance.

(a) In general

A controlled substance analogue shall, to the extent intended for human consumption, be treated, for the purposes of any Federal law as a controlled substance in schedule I.