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Is Peyote and Mescaline Legal? State by state

Peyote and Mescaline is legal to sell at retail in 0 states, restricted in 0, in a gray area in 0 and illegal in 51. Federal: federally scheduled or prohibited. Verified through November 12, 2026.

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QuietNo pending legislation, deadlines or enforcement actions on file for Peyote and Mescaline nationally.

What is Peyote and Mescaline?

Peyote, the small spineless cactus Lophophora williamsii, and its principal alkaloid mescaline; mescaline also occurs in San Pedro and other Trichocereus cacti sold as ornamentals. Both peyote and mescaline are federally Schedule I (21 CFR 1308.11(d)), with a federal exemption for bona fide religious use by members of the Native American Church (21 CFR 1307.31; 42 U.S.C. 1996a). State law tracks the federal listing and adds its own religious-use provisions.

Framework: CSA scheduling · Reference article

Legal 0 · Restricted 0 · Gray 0 · Illegal 51 · Not verified 0
LegalRestrictedGray areaIllegalNot yet verified

Federal posture

Federally scheduled or prohibited. Schedule I federally (peyote and mescaline); Native American Church exemption Federal detail and instruments

Status by state

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Compound Analytics. “Is Peyote and Mescaline Legal? State-by-State Map and Laws (2026).” Compound Laws, https://compoundlaws.com/compounds/peyote/. Accessed November 13, 2026.

Compound Laws, published by Compound Analytics, reports the record: statutes verbatim, official citations, enforcement facts and verification dates. Nothing here is legal advice and nothing here describes how to get around a law. A jurisdiction with no verified row is reported as not yet verified, never as legal. Found an error? Corrections policy.

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