Is Peyote and Mescaline Legal in Rhode Island? (2026)

Illegal

As of November 12, 2026, Peyote and Mescaline is illegal to sell (federally scheduled; state law on file reads illegal) in Rhode Island. Schedule I federally (peyote and mescaline); Native American Church exemption. Controlling source: R.I. Gen. Laws Sec. 21-28-2.01 Authority to control (as amended eff. 2025-02-01).

Verified November 12, 2026 (hash check) · confidence: confirmed

Is Peyote and Mescaline Legal? Every state and federal law

Rhode Island Peyote and Mescaline ban status: ban in force

QuietNo pending legislation, deadlines or enforcement actions on file for Peyote and Mescaline in Rhode Island.
Federal
Schedule I federally (peyote and mescaline); Native American Church exemption (effective 1971-05-01). State-law reading underneath: Illegal.
Rule type
permanent
Tier
Schedule I
Schedule
schedule 1
Effective
2025-02-01
Effectively prohibitive
yes, in practice

What the record says

Rhode Island no longer prints its own schedules: P.L. 2024, ch. 390 and 391 repealed the statutory list (R.I. Gen. Laws 21-28-2.08) effective Feb. 1, 2025 and amended 21-28-2.01 so that the director of health controls all substances enumerated in the most current version of Title 21 of the Code of Federal Regulations, which 21-28-2.01(c) makes the state list. The RIDOH Controlled Substance Listing (April 2026) says the same. 21 CFR 1308.11(d) lists Mescaline at (d)(24) and Peyote at (d)(26), defined as all parts of Lophophora williamsii Lemaire, whether growing or not, its seeds, extracts and every compound, salt, derivative, mixture or preparation. No Rhode Island statute names a Native American Church or sacramental exemption; the federal exemption at 21 CFR 1307.31 is a registration exemption outside the substance list, and whether the state adoption of the enumerated substances carries it is not stated. San Pedro and other mescaline cacti are not named; they are reached only through mescaline content. Federally Schedule I (see the federal page).

Controlling language, verbatim

(26) Peyote 7415 Meaning all parts of the plant presently classified botanically as Lophophora williamsii Lemaire, whether growing or not, the seeds thereof, any extract from any part of such plant, and every compound, manufacture, salts, derivative, mixture, or preparation of such plant, its seeds or extracts

Source of excerpt

Citations

  1. R.I. Gen. Laws Sec. 21-28-2.01 Authority to control (as amended eff. 2025-02-01) (Rhode Island General Assembly, 2026-10-31) PRIMARYOFFICIAL
  2. 21 CFR 1308.11(d)(24) Mescaline, (d)(26) Peyote (Office of the Federal Register / DEA (eCFR), 2026-10-31)OFFICIAL
  3. RIDOH Rhode Island Controlled Substance Listing, April 2026 (Rhode Island Department of Health, 2026-10-31)OFFICIAL
  4. P.L. 2024, ch. 390 (2024 H 7446 Sub A), enacted 2024-06-26, effective 2025-02-01 (Rhode Island General Assembly, 2026-10-31)OFFICIAL
  5. R.I. Gen. Laws Sec. 21-28-2.08 [Repealed] (repealed by P.L. 2024, ch. 390 and 391, eff. 2025-02-01) (Rhode Island General Assembly, 2026-10-31)OFFICIAL
  6. R.I. Gen. Laws Sec. 42-80.1-3 Religious freedom protected (Rhode Island General Assembly, 2026-10-31)OFFICIAL

Where Peyote and Mescaline stands across the country

LegalRestrictedGray areaIllegalNot yet verified

Among Rhode Island's 2 neighbors, Connecticut and Massachusetts are illegal, the same posture as Rhode Island.

Open the interactive map · Every compound in Rhode Island · Where Peyote and Mescaline is banned · Is San Pedro cactus legal? Every state · Embed this map

Federal posture

Federally scheduled or prohibited. Schedule I federally (peyote and mescaline); Native American Church exemption Federal detail

Verbatim law on file for Rhode Island

6 instruments on file for this compound’s framework in Rhode Island; 6 of 6 citations above are official sources. Each text carries its source and a fingerprint that changes when the law does.

R.I. Gen. Laws § 21-28-2.08(d) · Schedule I hallucinogenic substances (official text)OFFICIAL
Instrument
Schedule I hallucinogenic substances (official text)
Source
https://webserver.rilegislature.gov/Statutes/TITLE21/21-28/21-28-2.08.htm
Retrieved
2026-11-01
Fingerprint
08dcc3b4d4fe2932
Drotebanol
(d)
 Hallucinogenic Substances. 
Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation that contains any quantity of the following hallucinogenic substances, or that contains any of its salts, isomers, and salts of isomers whenever the existence of the salts, isomers, and salts of isomers is possible within the specific chemical designation (for purposes of this subsection only, the term "isomer" includes the optical, position, and geometric isomers):
(1)
R.I. Gen. Laws 11-48-2 · Sale, possession, and useOFFICIAL
Instrument
Sale, possession, and use
Source
https://webserver.rilegislature.gov/Statutes/TITLE11/11-48/11-48-2.htm
Retrieved
2026-10-31
Fingerprint
d0aa0eafd9477867
§ 11-48-2. Sale, possession, and use.

No person shall intentionally smell or inhale the fumes of any substance having the
            property of releasing toxic vapors for the purpose of causing a condition of intoxication,
            euphoria, excitement, exhilaration, stupefaction, or dulled senses or nervous system,
            nor possess, buy, or sell any substance for the purpose of violating or aiding another
            to violate this chapter; provided, that this chapter shall not apply to the inhalation
            of anesthesia for medical or dental purposes.
R.I. Gen. Laws 21-28-2.08, Schedule I(d) · Schedules: Schedule I hallucinogenic substancesOFFICIAL
Instrument
Schedules: Schedule I hallucinogenic substances
Source
https://webserver.rilegislature.gov/Statutes/TITLE21/21-28/21-28-2.08.htm
Retrieved
2026-10-29
Fingerprint
270927f40684dc5b
(d)
 Hallucinogenic Substances. 
Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation that contains any quantity of the following hallucinogenic substances, or that contains any of its salts, isomers, and salts of isomers whenever the existence of the salts, isomers, and salts of isomers is possible within the specific chemical designation (for purposes of this subsection only, the term "isomer" includes the optical, position, and geometric isomers):
(1)

3, 4-methylenedioxy amphetamine
(2)

5-methoxy-3, 4-methylenedioxy amphetamine
(3)

3, 4, 5-trimethoxy amphetamine
(4)

Bufotenine
(5)

Diethyltryptamine
(6)

Dimethyltryptamine
(7)

4-methyl 2, 5-dimethoxyamphetamine
(8)

Ibogaine
(9)

Lysergic acid diethylamide
(10)

Marihuana
(11)

Mescaline
(12)

Peyote. Meaning all parts of the plant presently classified botanically as Lophophora      Williamsii Lemair whether growing or not; the seeds of the plant; any extract from      any part of the plant; and any compound, manufacture, salt, derivative, mixture, or      preparation of the plant, its seeds or extracts.
(13)

N-ethyl-3-piperidyl benzilate
(14)

N-methyl-3-piperidyl benzilate
(15)

Psilocybin
(16)

Psilocyn
(17)

Tetrahydrocannabinols. Synthetic equivalents of the substances contained in the plant,      or in the resinous extractives of Cannabis, sp. and/or synthetic substances, derivatives,      and their isomers with similar chemical structure and pharmacological activity such      as the following: delta 1 cis or trans tetrahydrocannabinol, and their optical isomers.      Delta 6 cis or trans tetrahydrocannabinol and their optical isomers. Delta 3, 4 cis      or trans tetrahydrocannabinol and their optical isomer. (Since nomenclature of these      substances is not internationally standardized, compounds of these structures, regardless      of numerical designation of atomic positions covered).
(18)

Thiophene analog of phencyclidine. 1-(1-(2 thienyl) cyclo-hexyl) pipiridine: 2-Thienyl      analog of phencyclidine: TPCP
(19)

2,5 dimethoxyamphetamine
(20)

4-bromo-2,5-dimethoxyamphetamine, 4-bromo-2,5-dimethoxy-alpha-methylphenethyamine:      4-bromo-2,5-DMA
(21)

4-methoxyamphetamine-4-methoxy-alpha-methylphenethylaimine: paramethoxyamphetamine:      PMA
(22)

Ethylamine analog of phencyclidine. N-ethyl-1-phenylcyclohexylamine, (1-phenylcyclohexyl)      ethylamine, N-(1-phenylcyclophexyl) ethylamine, cyclohexamine, PCE
(23)

Pyrrolidine analog of phencyclidine. 1-(1-phencyclohexyl)-pyrrolidine PCPy, PHP
(24)

Parahexyl; some trade or other names: 3-Hexyl-1-hydroxy-7,8,9,10-tetrahydro-6,6,9-trimethyl-6H-dibenz      o (b,d) pyran: Synhexyl.
(25)

Salvia Divinorum (Salvinorin A or Divinorin A), meaning any extract from any part      of the plant, and any compound, salt derivative, or mixture of the plant or its extracts.      This shall not mean the unaltered plant.
(26)

Datura stamonium (jimsom weed or datura), meaning any extract from any part of the      plant, and any compound, salt derivative, or mixture of the plant or its extracts.      This shall not mean the unaltered plant.
Show 3 more laws on file
R.I. Gen. Laws Sec. 21-28-2.01(a)-(c) · Authority to control (state list is the current 21 CFR)OFFICIAL
Instrument
Authority to control (state list is the current 21 CFR)
Source
https://webserver.rilegislature.gov/Statutes/TITLE21/21-28/21-II/21-28-2.01.htm
Retrieved
2026-10-31
Fingerprint
b4c949bd466d4da3
(a)(1)
 The director of the department of health shall control all substances enumerated in
            the most current version of Title 21 of the Code of Federal Regulations (C.F.R.) and
            may by motion or on the petition of any interested party pursuant to the procedures
            of chapter 35 of title 42, the Administrative Procedures Act, add, reschedule, or delete a substance as a controlled
            substance. In making this determination, the director of health shall consider, but
            not be limited to the following:

(i)
 Its actual or relative potential for abuse;

(ii)
 Scientific evidence of its pharmacological effect if known;

(iii)
 State of current scientific knowledge regarding the substance;

(iv)
 Its history and current pattern of abuse;

(v)
 The scope, duration, and significance of abuse;

(vi)
 What, if any, risk there is to the public health;

(vii)
 Its psychic or physiological dependence liability;

(viii)
 Whether the substance is an immediate precursor of a substance already controlled
            under this chapter.

(2)
 After considering the factors in subdivision (1) of this section the director of health
            shall make findings with respect to these factors and shall issue an order controlling
            the substance if it is found that the substance has potential for abuse.

(b)
 If the director of health designates a substance as an immediate precursor, substances
            which are precursors of the controlled precursor shall not be subject to control solely
            because they are precursors of the controlled precursor.

(c)
 The director of the department of health shall reference the current version of Title
            21 of the C.F.R. as the current list of substances designated, rescheduled, or deleted
            as a controlled substance for the state. If the director objects to inclusion, rescheduling,
            or deletion of any substance under the current federal law, or if the director adds
            or reschedules a controlled substance pursuant to the authority provided in this chapter,
            the director shall file that decision with the secretary of state and post exempted
            substances on the department of health website.
R.I. Gen. Laws Sec. 21-28-2.01(c) · Authority to control: reference to current 21 CFROFFICIAL
Instrument
Authority to control: reference to current 21 CFR
Source
https://webserver.rilegislature.gov/Statutes/TITLE21/21-28/21-II/21-28-2.01.htm
Retrieved
2026-11-06
Fingerprint
ee72c3a8fb7ba56b
(c)
 The director of the department of health shall reference the current version of Title
            21 of the C.F.R. as the current list of substances designated, rescheduled, or deleted
            as a controlled substance for the state. If the director objects to inclusion, rescheduling,
            or deletion of any substance under the current federal law, or if the director adds
            or reschedules a controlled substance pursuant to the authority provided in this chapter,
            the director shall file that decision with the secretary of state and post exempted
            substances on the department of health website.
R.I. Gen. Laws Sec. 21-28-4.01(f) · Prohibited acts A, salvia divinorum and datura stramoniumOFFICIAL
Instrument
Prohibited acts A, salvia divinorum and datura stramonium
Source
https://webserver.rilegislature.gov/Statutes/TITLE21/21-28/21-IV/21-28-4.01.htm
Retrieved
2026-10-31
Fingerprint
53583706a9a4693d
(f)
 It is unlawful for any person to knowingly or intentionally possess, manufacture,
            distribute, or possess with intent to manufacture or distribute, any extract, compound,
            salt derivative, or mixture of salvia divinorum or datura stramonium or its extracts
            unless the person is exempt pursuant to the provisions of § 21-28-3.30. Notwithstanding any laws to the contrary, any person who violates this section is
            guilty of a misdemeanor and, upon conviction, may be imprisoned for not more than
            one year, or fined not more than one thousand dollars ($1,000), or both. The provisions
            of this section shall not apply to licensed physicians, pharmacists, and accredited
            hospitals and teaching facilities engaged in the research or study of salvia divinorum
            or datura stramonium and shall not apply to any person participating in clinical trials
            involving the use of salvia divinorum or datura stramonium.

Peyote and Mescaline in neighboring states

Peyote and Mescaline in 48 other states

Closest to Peyote and Mescaline in Rhode Island

Same framework in Rhode Island

23 other compounds in Rhode Island

Cite this page

Compound Analytics. “Is Peyote and Mescaline Legal in Rhode Island? Updated Nov 2026.” Compound Laws, https://compoundlaws.com/compounds/peyote/rhode-island/. Accessed November 13, 2026.

Compound Laws, published by Compound Analytics, reports the record: statutes verbatim, official citations, enforcement facts and verification dates. Nothing here is legal advice and nothing here describes how to get around a law. A jurisdiction with no verified row is reported as not yet verified, never as legal. Found an error? Corrections policy.

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