Mitragynine Pseudoindoxyl updates: every status change, dated

The most recent Mitragynine Pseudoindoxyl record correction on file is November 3, 2026: Georgia, record corrected. status now shown: illegal. 38 changes recorded in total.

Subscribe: RSS for Mitragynine Pseudoindoxyl. Pending items appear in the Watch band; they are not changes until they take effect.

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Hotearliest DEA action in 0 days (DEA-1570 / FR 2026-20943); notice of intent by the DEA (Drug Enforcement Administration), applies to every seller; enforcement action by the federal court (U.S. Attorney's Office, Northern District of Mississippi, with DEA), binds named parties only

Earliest Nov 13, 2026
DEA to replace pseudoindoxyl Schedule I order with a threshold order (re-notice)
Federal · Enforcement date · DEA-1570 / FR 2026-20943
DEA may act on or after this date. An order takes effect on publication with no grace period.
active October 14, 2026
DEA re-notices intent to place 7-OH and mitragynine pseudoindoxyl above 1 mg/g (or 1 mg/mL) or below a 100:1 mitragynine ratio in Schedule I; withdraws July 2026 notice
Federal · Notice of intent · DEA-1570; FR Doc. 2026-20943 · DEA (Drug Enforcement Administration) · applies to every seller
Products exceeding 1 mg per gram (solids) or 1 mg per mL (liquids) of 7-OH alone or combined with pseudoindoxyl, or with a mitragynine-to-7-OH mass ratio under 100, would be Schedule I; the order cannot issue before 30 days after publication (on or after November 13, 2026) and would run two years.
active October 14, 2026
DEA notice of intent to issue a new temporary order keeping MGM-15 and MGM-16 in Schedule I without a threshold
Federal · Notice of intent · DEA-1644; FR Doc. 2026-20942 · DEA (Drug Enforcement Administration) · applies to every seller
DEA will issue a fresh two-year temporary order for MGM-15 and MGM-16 (no threshold) so they are separated from the thresholded pseudoindoxyl rule; the August 26, 2026 order stays in force until the new order publishes or expires August 26, 2028.
active October 1, 2026
Federal prosecutors charge an Oxford, Mississippi vape store clerk and his son with possession with intent to distribute after kratom-alkaloid pills tied to two Ole Miss student deaths tested for a DEA Schedule I compound
Mississippi · Enforcement action · Federal court (U.S. Attorney's Office, Northern District of Mississippi, with DEA) · binds named parties only
An informant bought kratom-based pills September 24, 2026; a DEA affidavit says a compound from the August 26, 2026 temporary scheduling order was listed as an ingredient; each defendant faces one count of possession with intent to distribute a controlled substance.
active August 26, 2026
DEA temporary scheduling order places mitragynine pseudoindoxyl, MGM-15 and MGM-16 in Schedule I for two years
Federal · Emergency rule · DEA-1644; 91 FR 54948; FR Doc. 2026-17429 · DEA (Drug Enforcement Administration) · applies to every seller
Mitragynine pseudoindoxyl, MGM-15 (dihydro-7-hydroxymitragynine) and MGM-16 (9-fluoro-dihydro-7-hydroxymitragynine), with isomers, esters, ethers and salts, became Schedule I effective August 26, 2026 through August 26, 2028; DOJ announced enforcement discretion for incidental trace pseudoindoxyl in botanical kratom.
active July 6, 2026
Notice of intent to temporarily schedule mitragynine pseudoindoxyl, MGM-15 and MGM-16
Federal · Notice of intent · FR 2026-13581 / 91 FR 40909 · DEA (U.S. Drug Enforcement Administration) · advisory, not binding
Order "will be published in the Federal Register on or after August 5, 2026" and takes effect on publication. This is the single highest-value watch item for pseudoindoxyl -- it would replace interpretive isomer capture in AL, AR, IN and WI with a NAMED federal basis. Speciociliatine is in NEITHER docket.
active June 22, 2026
Florida AG signs expanded emergency rule scheduling 7-OH and six related compounds (including pseudoindoxyl, MGM-15, MGM-16) as Schedule I above 1 mg/g or below a 100:1 mitragynine ratio
Florida · Emergency rule · Attorney General (Florida Attorney General James Uthmeier) · applies to every seller
Products may contain no more than 1 mg per gram (solids) or per mL (liquids) of 7-hydroxymitragynine, mitragynine pseudoindoxyl, 7-acetoxymitragynine, 9-hydroxycorynantheidine, 10-hydroxycorynantheidine, MGM-15 or MGM-16, and must contain at least 100 times more mitragynine by mass; violations are felony-level.
October 13, 2026
Schedules of Controlled Substances: Temporary Placement of MGM-15 and MGM-16 in Schedule I
Federal · Signal
final August 26, 2026
DOJ announces emergency scheduling of three 7-OH-related compounds and an enforcement-discretion policy for trace pseudoindoxyl in botanical kratom
Federal · Guidance · DEA (U.S. Department of Justice / Drug Enforcement Administration) · applies to every seller
DOJ stated it will exercise enforcement discretion where only incidental trace mitragynine pseudoindoxyl is confirmed in a product otherwise consistent with botanical kratom; the policy does not apply to MGM-15, MGM-16 or concentrated or added pseudoindoxyl and creates no legal exemption.
settled June 10, 2026
Relax Relief Rejuvenate (RRR) Trading settlement
Missouri · Settlement · Cole County · Attorney General (Missouri Attorney General) · binds named parties only
Enumerates 7-OH, MGM-15, mitragynine, mitragynine pseudoindoxyl and paynantheine -- notably NOT speciociliatine.

Change log

2026-11-03Georgia: Record corrected. Status now shown: Illegal.
2026-11-03Kentucky: Record corrected. Status now shown: Illegal.
2026-11-03Maryland: Record corrected. Status now shown: Illegal.
2026-11-03Missouri: Record corrected. Status now shown: Illegal.
2026-11-03Oklahoma: Record corrected. Status now shown: Illegal.
2026-11-03Rhode Island: Record corrected. Status now shown: Illegal.
2026-09-23Arizona: Status changed from illegal to restricted.
2026-09-23Mississippi: Status changed from illegal to restricted.
2026-09-23Colorado: Status changed from illegal to restricted.
2026-09-23Georgia: Status changed from illegal to restricted.
2026-09-23Kentucky: Status changed from illegal to restricted.
2026-09-23Maryland: Status changed from illegal to restricted.
2026-09-23Missouri: Status changed from illegal to restricted.
2026-09-23Nebraska: Status changed from illegal to restricted.
2026-09-23Oklahoma: Status changed from illegal to restricted.
2026-09-23Oregon: Status changed from illegal to restricted.
2026-09-23Rhode Island: Status changed from illegal to restricted.
2026-09-23Texas: Status changed from illegal to restricted.
2026-09-23Virginia: Status changed from illegal to restricted.
2026-09-23Wisconsin: Status changed from illegal to restricted.
2026-09-23Wyoming: Status changed from illegal to restricted.
2026-09-23Colorado: Status changed from restricted to illegal.
2026-09-23Arizona: Status changed from restricted to illegal.
2026-09-23Georgia: Status changed from restricted to illegal.
2026-09-23Kentucky: Status changed from restricted to illegal.
2026-09-23Maryland: Status changed from restricted to illegal.
2026-09-23Missouri: Status changed from restricted to illegal.
2026-09-23Mississippi: Status changed from restricted to illegal.
2026-09-23Nebraska: Status changed from restricted to illegal.
2026-09-23Oklahoma: Status changed from restricted to illegal.
2026-09-23Oregon: Status changed from restricted to illegal.
2026-09-23Rhode Island: Status changed from restricted to illegal.
2026-09-23Texas: Status changed from restricted to illegal.
2026-09-23Virginia: Status changed from restricted to illegal.
2026-09-23Wisconsin: Status changed from restricted to illegal.
2026-09-23Wyoming: Status changed from restricted to illegal.
2026-09-22Massachusetts: Status changed from legal to illegal.
2026-09-22North Dakota: Status changed from legal to illegal.

Mitragynine Pseudoindoxyl by state · Where Mitragynine Pseudoindoxyl is banned · All changes

Compound Laws, published by Compound Analytics, reports the record: statutes verbatim, official citations, enforcement facts and verification dates. Nothing here is legal advice and nothing here describes how to get around a law. A jurisdiction with no verified row is reported as not yet verified, never as legal. Found an error? Corrections policy.

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Mitragynine Pseudoindoxyl updates: every status change, dated

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