Is 4-AcO-DMT (Psilacetin) Legal in Pennsylvania? (2026)

Gray area

As of November 12, 2026, 4-AcO-DMT (Psilacetin) is in a legal gray area (sold in practice, exposed to an interpretive ban theory) in Pennsylvania. Pennsylvania does not name 4-AcO-DMT; designer drug offense may reach it. Controlling source: Controlled Substance, Drug, Device and Cosmetic Act, Secs. 2, 13(a)(36), 13(l).

Verified November 12, 2026 (hash check) · confidence: under review

Is 4-AcO-DMT Legal? Every state and federal law

WatchNo pending legislation, deadlines or enforcement actions on file for 4-AcO-DMT in Pennsylvania.
Rule type
permanent
Tier
Analog exposed
Schedule
schedule 1

What the record says

Section 4(1)(iii) of the Controlled Substance, Drug, Device and Cosmetic Act lists psilocybin and psilocyn but not 4-AcO-DMT, with salts and isomers only; the Department of Health schedule at 28 Pa. Code 25.72 mirrors it. The act defines a designer drug as a non-controlled substance intended for human consumption with a chemical structure substantially similar to a Schedule I, II or III substance, or producing a substantially similar effect, and Sec. 13(a)(36) makes knowing manufacture, distribution or possession with intent to distribute a felony. Mere possession is not stated. Application to 4-AcO-DMT is a fact question.

Controlling language, verbatim

(36)  The knowing or intentional manufacture, distribution, possession with intent to distribute, or possession of a designer drug.

Source of excerpt

Citations

  1. Controlled Substance, Drug, Device and Cosmetic Act, Secs. 2, 13(a)(36), 13(l) (Pennsylvania General Assembly, 2026-11-06) PRIMARYOFFICIAL
  2. 28 Pa. Code 25.72 Schedules of controlled substances (Pennsylvania Code and Bulletin, 2026-11-06)OFFICIAL
  3. HB 1439 (2025-2026) (Pennsylvania General Assembly, 2026-11-06)OFFICIAL
  4. SB 1149 (2025-2026) (Pennsylvania General Assembly, 2026-11-06)OFFICIAL

Where 4-AcO-DMT (Psilacetin) stands across the country

LegalRestrictedGray areaIllegalNot yet verified

Among Pennsylvania's 6 neighbors, West Virginia is illegal; Delaware, Maryland, New Jersey and Ohio are gray area; New York is legal.

Open the interactive map · Every compound in Pennsylvania · Where 4-AcO-DMT is banned · What is in mushroom gummies · Embed this map

Federal posture

Federal gray area. Not named in federal schedules; Analogue Act exposure (psilocin analogue) Federal detail

Verbatim law on file for Pennsylvania

8 instruments on file for this compound’s framework in Pennsylvania; 4 of 4 citations above are official sources. Each text carries its source and a fingerprint that changes when the law does.

18 Pa.C.S. 7303 · Sale or illegal use of certain solvents and noxious substancesOFFICIAL
Instrument
Sale or illegal use of certain solvents and noxious substances
Source
https://www.legis.state.pa.us/WU01/LI/LI/CT/HTM/18/00.073.003.000..HTM
Retrieved
2026-10-31
Fingerprint
d2e4f5e93dba34df
§ 7303.  Sale or illegal use of certain solvents and noxious substances.

(a)  Offense defined.--
No person shall, for the purpose of causing a condition of intoxication, inebriation,
            excitement, stupefaction, or the dulling of his brain or nervous system, intentionally
            smell or inhale the fumes from any noxious substance or substance containing a solvent
            having the property of releasing toxic vapors or fumes.

(b)  Exception.--
Subsection (a) of this section shall not apply to the inhalation of any anesthesia
            for medical or dental purposes.

(c)  Possession prohibited.--
No person shall, for the purpose of violating subsection (a) of this section, use,
            or possess for the purpose of so using, any noxious substance or substance containing
            a solvent having the property of releasing toxic vapors or fumes.

(d)  Sale prohibited.--
No person shall sell at retail, or offer to sell, to any other person any tube or
            other container of any noxious substance or substance containing a solvent having
            the property of releasing toxic vapors or fumes, if he has reasonable cause to suspect
            that the product sold, or offered for sale, will be used for the purpose set forth
            in subsection (a) of this section.

(e)  Grading.--
Any person who violates any provision of this section shall be guilty of a misdemeanor
            of the third degree.

(f)  Definition.--
As used in this section, the phrase "any noxious substance or substance containing
            a solvent having the property of releasing toxic vapors or fumes" shall mean any substance
            containing one or more of the following chemical compounds: acetone, acetate, benzene,
            butyl alcohol, cyclohexyl nitrite, ethyl alcohol, ethylene dichloride, gaseous or
            liquid fluorocarbons, isopropyl alcohol, methyl alcohol, methyl ethyl ketone, nitrous
            oxide, pentachlorophenol, petroleum ether, or toluene.
35 P.S. § 780-102(b) (designer drug); 35 P.S. § 780-104(1)(iii) (Schedule I hallucinogens), Act of Apr. 14, 1972, P.L. 233, No. 64 · Designer drug definition; Schedule I hallucinogenic substancesOFFICIAL
Instrument
Designer drug definition; Schedule I hallucinogenic substances
Source
https://www.legis.state.pa.us/WU01/LI/LI/US/HTM/1972/0/0064..HTM
Retrieved
2026-10-29
Fingerprint
f3de2554dbf25382
"Designer drug" means a substance other than a controlled substance that is intended
            for human consumption and that either has a chemical structure substantially similar
            to that of a controlled substance in Schedules I, II or III of this act or that produces
            an effect substantially similar to that of a controlled substance in Schedules I,
            II or III. Examples of chemical classes in which designer drugs are found include,
            but are not limited to, the following: Phenethylamines, N-substituted piperidines,
            morphinans, ecgonines, quinazolinones, substituted indoles and arylcycloalkylamines.
            (Def. amended Feb. 11, 2000, P.L.9, No.3)

(iii)  Any material, compound, mixture, or preparation which contains any quantity of the
            following hallucinogenic substances, their salts, isomers, and salts of isomers, unless
            specifically excepted, whenever the existence of such salts, isomers, and salts of
            isomers is possible within the specific chemical designation:

1.  3,4-methylenedioxy amphetamine.

2.  5-methoxy-3,4-methylenedioxy amphetamine.

3.  3,4,5-trimethoxy amphetamine.

4.  Bufotenine.

5.  Diethyltryptamine.

6.  Dimethyltryptamine.

7.  4-methyl-2,5-dimethoxyamphetamine.

8.  Ibogaine.

9.  Lysergic acid diethylamide.

10.  Mescaline.

11.  Peyote.

12.  N-ethyl-3-piperidyl benzilate.

13.  N-methyl-3-piperidyl benzilate.

14.  Psilocybin.

15.  Psilocyn.

16.  Tetrahydrocannabinols.

17.  Salvia Divinorum.

18.  Salvinorin A.

19.  Divinorin A.

20.  3,4-Methylenedioxymethcathinone (Methylone).

21.  3,4-Methylenedioxypyrovalerone (MDPV).

22.  4-Methylmethcathinone (Mephedrone).

23.  4-Methoxymethcathinone.

24.  4-Fluoromethcathinone.

25.  3-Fluoromethcathinone.

26.  3,4-Methylenedioxymethamphetamine.

27.  Methoxetamine.

((iii) amended June 8, 2016, P.L.258, No.37)
35 P.S. 780-102 "Designer drug"; 35 P.S. 780-113(a)(36) and (l) · Designer drug definition, prohibited act and penaltyOFFICIAL
Instrument
Designer drug definition, prohibited act and penalty
Source
https://www.legis.state.pa.us/WU01/LI/LI/US/HTM/1972/0/0064..HTM
Retrieved
2026-11-06
Fingerprint
04a3f16a6f1b25d2
"Designer drug" means a substance other than a controlled substance that is intended
            for human consumption and that either has a chemical structure substantially similar
            to that of a controlled substance in Schedules I, II or III of this act or that produces
            an effect substantially similar to that of a controlled substance in Schedules I,
            II or III. Examples of chemical classes in which designer drugs are found include,
            but are not limited to, the following: Phenethylamines, N-substituted piperidines,
            morphinans, ecgonines, quinazolinones, substituted indoles and arylcycloalkylamines.
            (Def. amended Feb. 11, 2000, P.L.9, No.3)

(36)  The knowing or intentional manufacture, distribution, possession with intent to distribute,
            or possession of a designer drug. Nothing in this section shall be construed to apply
            to a person who manufactures or distributes a substance in conformance with the provisions
            of an approved new drug application or an exemption for investigational use within
            the meaning of section 505 of the Federal Food, Drug and Cosmetic Act (21 U.S.C. §
            355). For purposes of this section, no new drug shall be introduced or delivered for
            introduction except upon approval of an application pursuant to section 505 of the
            Federal Food, Drug and Cosmetic Act. ((36) amended Feb. 11, 2000, P.L.9, No.3)

(l)  Any person who violates clause (36) is guilty of a felony and upon conviction thereof
            shall be sentenced to imprisonment not exceeding fifteen years or to pay a fine not
            exceeding two hundred fifty thousand dollars ($250,000), or both. ((l) added Dec.
            11, 1986, P.L.1488, No.154)
Show 5 more laws on file
35 P.S. 780-104(1)(iii) · Schedule I, hallucinogenic substancesOFFICIAL
Instrument
Schedule I, hallucinogenic substances
Source
https://www.legis.state.pa.us/WU01/LI/LI/US/HTM/1972/0/0064..HTM
Retrieved
2026-10-31
Fingerprint
f067bfbed3256017
(iii)  Any material, compound, mixture, or preparation which contains any quantity of the
            following hallucinogenic substances, their salts, isomers, and salts of isomers, unless
            specifically excepted, whenever the existence of such salts, isomers, and salts of
            isomers is possible within the specific chemical designation:

1.  3,4-methylenedioxy amphetamine.

2.  5-methoxy-3,4-methylenedioxy amphetamine.

3.  3,4,5-trimethoxy amphetamine.

4.  Bufotenine.

5.  Diethyltryptamine.

6.  Dimethyltryptamine.

7.  4-methyl-2,5-dimethoxyamphetamine.

8.  Ibogaine.

9.  Lysergic acid diethylamide.

10.  Mescaline.

11.  Peyote.

12.  N-ethyl-3-piperidyl benzilate.

13.  N-methyl-3-piperidyl benzilate.

14.  Psilocybin.

15.  Psilocyn.

16.  Tetrahydrocannabinols.

17.  Salvia Divinorum.

18.  Salvinorin A.

19.  Divinorin A.

20.  3,4-Methylenedioxymethcathinone (Methylone).

21.  3,4-Methylenedioxypyrovalerone (MDPV).

22.  4-Methylmethcathinone (Mephedrone).

23.  4-Methoxymethcathinone.

24.  4-Fluoromethcathinone.

25.  3-Fluoromethcathinone.

26.  3,4-Methylenedioxymethamphetamine.

27.  Methoxetamine.
35 P.S. 780-104(3)(ix) · Schedule III, ketamineOFFICIAL
Instrument
Schedule III, ketamine
Source
https://www.legis.state.pa.us/WU01/LI/LI/US/HTM/1972/0/0064..HTM
Retrieved
2026-10-31
Fingerprint
90ef6a9368fc68c0
(ix)  Ketamine, any salt, ketamine compound, derivative or preparation of ketamine, including
            any isomers, esters and ethers and salts of isomers, esters and ethers of ketamine.
35 P.S. 780-113(a)(36) · Prohibited acts: designer drugOFFICIAL
Instrument
Prohibited acts: designer drug
Source
https://www.legis.state.pa.us/WU01/LI/LI/US/HTM/1972/0/0064..HTM
Retrieved
2026-11-01
Fingerprint
ffb7dfd39c6512b4
(36)  The knowing or intentional manufacture, distribution, possession with intent to distribute,
            or possession of a designer drug. Nothing in this section shall be construed to apply
            to a person who manufactures or distributes a substance in conformance with the provisions
            of an approved new drug application or an exemption for investigational use within
            the meaning of section 505 of the Federal Food, Drug and Cosmetic Act (21 U.S.C. §
            355). For purposes of this section, no new drug shall be introduced or delivered for
            introduction except upon approval of an application pursuant to section 505 of the
            Federal Food, Drug and Cosmetic Act. ((36) amended Feb. 11, 2000, P.L.9, No.3)
35 P.S. Sec. 780-102 (designer drug) with operative offense at 35 P.S. Sec. 780-113(a)(36) · Definition of designer drug; prohibited act (manufacture/distribute/possess a designer drug)OFFICIAL
Instrument
Definition of designer drug; prohibited act (manufacture/distribute/possess a designer drug)
Source
https://www.pa.gov/content/dam/copapwp-pagov/en/health/documents/topics/documents/laws-and-regulations/DDC_Act.pdf
Retrieved
2026-07-20
Fingerprint
5afcded3d3e31998
35 P.S. Sec. 780-102. "Designer drug" means a substance other than a controlled substance that is intended for human consumption and that either has a chemical structure substantially similar to that of a controlled substance in Schedules I, II or III of this act or that produces an effect substantially similar to that of a controlled substance in Schedules I, II or III. Examples of chemical classes in which designer drugs are found include, but are not limited to, the following: Phenethylamines, N-substituted piperidines, morphinans, ecgonines, quinazolinones, substituted indoles and arylcyloalkylamines. (Def. added Dec. 22, 1989, P.L.769, No.107, amended February 11, 2000, P.L. 9, No. 3)

35 P.S. Sec. 780-113(a)(36). The knowing or intentional manufacture, distribution, possession with intent to distribute, or possession of a designer drug. Nothing in this section shall be construed to apply to a person who manufactures or distributes a substance in conformance with the provisions of an approved new drug application or an exemption for investigational use within the meaning of section 505 of the Federal Food, Drug and Cosmetic Act (21 U.S.C. Section 355). For purposes of this section, no new drug shall be introduced or delivered for introduction except upon approval of an application pursuant to section 505 of the Federal Food, Drug and Cosmetic Act. ((36) amended February 11, 2000, P.L. 9, No. 3)
35 P.S. Sec. 780-104(1)(iii) (Controlled Substance, Drug, Device and Cosmetic Act, Sec. 4, Schedule I hallucinogens) · Schedule I: hallucinogenic substancesOFFICIAL
Instrument
Schedule I: hallucinogenic substances
Source
https://www.legis.state.pa.us/WU01/LI/LI/US/HTM/1972/0/0064..HTM
Retrieved
2026-10-28
Fingerprint
292641e71acad678
(iii)  Any material, compound, mixture, or preparation which contains any quantity of the
            following hallucinogenic substances, their salts, isomers, and salts of isomers, unless
            specifically excepted, whenever the existence of such salts, isomers, and salts of
            isomers is possible within the specific chemical designation:

1.  3,4-methylenedioxy amphetamine.

2.  5-methoxy-3,4-methylenedioxy amphetamine.

3.  3,4,5-trimethoxy amphetamine.

4.  Bufotenine.

5.  Diethyltryptamine.

6.  Dimethyltryptamine.

7.  4-methyl-2,5-dimethoxyamphetamine.

8.  Ibogaine.

9.  Lysergic acid diethylamide.

10.  Mescaline.

11.  Peyote.

12.  N-ethyl-3-piperidyl benzilate.

13.  N-methyl-3-piperidyl benzilate.

14.  Psilocybin.

15.  Psilocyn.

16.  Tetrahydrocannabinols.

17.  Salvia Divinorum.

18.  Salvinorin A.

19.  Divinorin A.

20.  3,4-Methylenedioxymethcathinone (Methylone).

21.  3,4-Methylenedioxypyrovalerone (MDPV).

22.  4-Methylmethcathinone (Mephedrone).

23.  4-Methoxymethcathinone.

24.  4-Fluoromethcathinone.

25.  3-Fluoromethcathinone.

26.  3,4-Methylenedioxymethamphetamine.

27.  Methoxetamine.

((iii) amended June 8, 2016, P.L.258, No.37)

4-AcO-DMT (Psilacetin) in neighboring states

4-AcO-DMT in 44 other states

Closest to 4-AcO-DMT in Pennsylvania

Same framework in Pennsylvania

23 other compounds in Pennsylvania

Cite this page

Compound Analytics. "Is 4-AcO-DMT (Psilacetin) Legal in Pennsylvania? Updated Nov 2026." Compound Laws, https://compoundlaws.com/compounds/4-aco-dmt/pennsylvania/. Accessed November 13, 2026.

Compound Laws, published by Compound Analytics, reports the record: statutes verbatim, official citations, enforcement facts and verification dates. Nothing here is legal advice and nothing here describes how to get around a law. A jurisdiction with no verified row is reported as not yet verified, never as legal. Found an error? Corrections policy.

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