As of November 12, 2026, 5-MeO-DMT is illegal to sell (federally scheduled; state law on file reads gray area) in Pennsylvania. Schedule I federally (21 CFR 1308.11(d)(15), code 7431), effective 2011-01-19. Controlling source: Controlled Substance, Drug, Device and Cosmetic Act, Secs. 2, 3, 13(a)(36), 13(l).
Verified November 12, 2026 (hash check) · confidence: under reviewIs 5-MeO-DMT Legal? Every state and federal law
Pennsylvania 5-MeO-DMT ban status: ban in force
Section 4(1)(iii) of the Controlled Substance, Drug, Device and Cosmetic Act and 28 Pa. Code 25.72 name DMT, DET, bufotenine, psilocybin and psilocyn, and 5-MeO-DIPT, but not 5-MeO-DMT. Sec. 3(c)(1) lets the Secretary reschedule a substance to coincide with federal law by notice; it is permissive, not automatic, and no such notice for 5-MeO-DMT was found. The designer drug definition (structure or effect substantially similar to a Schedule I, II or III substance) and Sec. 13(a)(36) cover manufacture, distribution or possession with intent to distribute. Application is a fact question.
(36) The knowing or intentional manufacture, distribution, possession with intent to distribute, or possession of a designer drug.
Among Pennsylvania's 6 neighbors, Delaware, Maryland, New Jersey, New York, Ohio and West Virginia are illegal, the same posture as Pennsylvania.
Open the interactive map · Every compound in Pennsylvania · Where 5-MeO-DMT is banned · Embed this map
Federally scheduled or prohibited. Schedule I federally (21 CFR 1308.11(d)(15), code 7431), effective 2011-01-19 Federal detail
8 instruments on file for this compound’s framework in Pennsylvania; 2 of 2 citations above are official sources. Each text carries its source and a fingerprint that changes when the law does.
d2e4f5e93dba34df§ 7303. Sale or illegal use of certain solvents and noxious substances.
(a) Offense defined.--
No person shall, for the purpose of causing a condition of intoxication, inebriation,
excitement, stupefaction, or the dulling of his brain or nervous system, intentionally
smell or inhale the fumes from any noxious substance or substance containing a solvent
having the property of releasing toxic vapors or fumes.
(b) Exception.--
Subsection (a) of this section shall not apply to the inhalation of any anesthesia
for medical or dental purposes.
(c) Possession prohibited.--
No person shall, for the purpose of violating subsection (a) of this section, use,
or possess for the purpose of so using, any noxious substance or substance containing
a solvent having the property of releasing toxic vapors or fumes.
(d) Sale prohibited.--
No person shall sell at retail, or offer to sell, to any other person any tube or
other container of any noxious substance or substance containing a solvent having
the property of releasing toxic vapors or fumes, if he has reasonable cause to suspect
that the product sold, or offered for sale, will be used for the purpose set forth
in subsection (a) of this section.
(e) Grading.--
Any person who violates any provision of this section shall be guilty of a misdemeanor
of the third degree.
(f) Definition.--
As used in this section, the phrase "any noxious substance or substance containing
a solvent having the property of releasing toxic vapors or fumes" shall mean any substance
containing one or more of the following chemical compounds: acetone, acetate, benzene,
butyl alcohol, cyclohexyl nitrite, ethyl alcohol, ethylene dichloride, gaseous or
liquid fluorocarbons, isopropyl alcohol, methyl alcohol, methyl ethyl ketone, nitrous
oxide, pentachlorophenol, petroleum ether, or toluene.f3de2554dbf25382"Designer drug" means a substance other than a controlled substance that is intended
for human consumption and that either has a chemical structure substantially similar
to that of a controlled substance in Schedules I, II or III of this act or that produces
an effect substantially similar to that of a controlled substance in Schedules I,
II or III. Examples of chemical classes in which designer drugs are found include,
but are not limited to, the following: Phenethylamines, N-substituted piperidines,
morphinans, ecgonines, quinazolinones, substituted indoles and arylcycloalkylamines.
(Def. amended Feb. 11, 2000, P.L.9, No.3)
(iii) Any material, compound, mixture, or preparation which contains any quantity of the
following hallucinogenic substances, their salts, isomers, and salts of isomers, unless
specifically excepted, whenever the existence of such salts, isomers, and salts of
isomers is possible within the specific chemical designation:
1. 3,4-methylenedioxy amphetamine.
2. 5-methoxy-3,4-methylenedioxy amphetamine.
3. 3,4,5-trimethoxy amphetamine.
4. Bufotenine.
5. Diethyltryptamine.
6. Dimethyltryptamine.
7. 4-methyl-2,5-dimethoxyamphetamine.
8. Ibogaine.
9. Lysergic acid diethylamide.
10. Mescaline.
11. Peyote.
12. N-ethyl-3-piperidyl benzilate.
13. N-methyl-3-piperidyl benzilate.
14. Psilocybin.
15. Psilocyn.
16. Tetrahydrocannabinols.
17. Salvia Divinorum.
18. Salvinorin A.
19. Divinorin A.
20. 3,4-Methylenedioxymethcathinone (Methylone).
21. 3,4-Methylenedioxypyrovalerone (MDPV).
22. 4-Methylmethcathinone (Mephedrone).
23. 4-Methoxymethcathinone.
24. 4-Fluoromethcathinone.
25. 3-Fluoromethcathinone.
26. 3,4-Methylenedioxymethamphetamine.
27. Methoxetamine.
((iii) amended June 8, 2016, P.L.258, No.37)04a3f16a6f1b25d2"Designer drug" means a substance other than a controlled substance that is intended
for human consumption and that either has a chemical structure substantially similar
to that of a controlled substance in Schedules I, II or III of this act or that produces
an effect substantially similar to that of a controlled substance in Schedules I,
II or III. Examples of chemical classes in which designer drugs are found include,
but are not limited to, the following: Phenethylamines, N-substituted piperidines,
morphinans, ecgonines, quinazolinones, substituted indoles and arylcycloalkylamines.
(Def. amended Feb. 11, 2000, P.L.9, No.3)
(36) The knowing or intentional manufacture, distribution, possession with intent to distribute,
or possession of a designer drug. Nothing in this section shall be construed to apply
to a person who manufactures or distributes a substance in conformance with the provisions
of an approved new drug application or an exemption for investigational use within
the meaning of section 505 of the Federal Food, Drug and Cosmetic Act (21 U.S.C. §
355). For purposes of this section, no new drug shall be introduced or delivered for
introduction except upon approval of an application pursuant to section 505 of the
Federal Food, Drug and Cosmetic Act. ((36) amended Feb. 11, 2000, P.L.9, No.3)
(l) Any person who violates clause (36) is guilty of a felony and upon conviction thereof
shall be sentenced to imprisonment not exceeding fifteen years or to pay a fine not
exceeding two hundred fifty thousand dollars ($250,000), or both. ((l) added Dec.
11, 1986, P.L.1488, No.154)f067bfbed3256017(iii) Any material, compound, mixture, or preparation which contains any quantity of the
following hallucinogenic substances, their salts, isomers, and salts of isomers, unless
specifically excepted, whenever the existence of such salts, isomers, and salts of
isomers is possible within the specific chemical designation:
1. 3,4-methylenedioxy amphetamine.
2. 5-methoxy-3,4-methylenedioxy amphetamine.
3. 3,4,5-trimethoxy amphetamine.
4. Bufotenine.
5. Diethyltryptamine.
6. Dimethyltryptamine.
7. 4-methyl-2,5-dimethoxyamphetamine.
8. Ibogaine.
9. Lysergic acid diethylamide.
10. Mescaline.
11. Peyote.
12. N-ethyl-3-piperidyl benzilate.
13. N-methyl-3-piperidyl benzilate.
14. Psilocybin.
15. Psilocyn.
16. Tetrahydrocannabinols.
17. Salvia Divinorum.
18. Salvinorin A.
19. Divinorin A.
20. 3,4-Methylenedioxymethcathinone (Methylone).
21. 3,4-Methylenedioxypyrovalerone (MDPV).
22. 4-Methylmethcathinone (Mephedrone).
23. 4-Methoxymethcathinone.
24. 4-Fluoromethcathinone.
25. 3-Fluoromethcathinone.
26. 3,4-Methylenedioxymethamphetamine.
27. Methoxetamine.90ef6a9368fc68c0(ix) Ketamine, any salt, ketamine compound, derivative or preparation of ketamine, including
any isomers, esters and ethers and salts of isomers, esters and ethers of ketamine.ffb7dfd39c6512b4(36) The knowing or intentional manufacture, distribution, possession with intent to distribute,
or possession of a designer drug. Nothing in this section shall be construed to apply
to a person who manufactures or distributes a substance in conformance with the provisions
of an approved new drug application or an exemption for investigational use within
the meaning of section 505 of the Federal Food, Drug and Cosmetic Act (21 U.S.C. §
355). For purposes of this section, no new drug shall be introduced or delivered for
introduction except upon approval of an application pursuant to section 505 of the
Federal Food, Drug and Cosmetic Act. ((36) amended Feb. 11, 2000, P.L.9, No.3)5afcded3d3e3199835 P.S. Sec. 780-102. "Designer drug" means a substance other than a controlled substance that is intended for human consumption and that either has a chemical structure substantially similar to that of a controlled substance in Schedules I, II or III of this act or that produces an effect substantially similar to that of a controlled substance in Schedules I, II or III. Examples of chemical classes in which designer drugs are found include, but are not limited to, the following: Phenethylamines, N-substituted piperidines, morphinans, ecgonines, quinazolinones, substituted indoles and arylcyloalkylamines. (Def. added Dec. 22, 1989, P.L.769, No.107, amended February 11, 2000, P.L. 9, No. 3) 35 P.S. Sec. 780-113(a)(36). The knowing or intentional manufacture, distribution, possession with intent to distribute, or possession of a designer drug. Nothing in this section shall be construed to apply to a person who manufactures or distributes a substance in conformance with the provisions of an approved new drug application or an exemption for investigational use within the meaning of section 505 of the Federal Food, Drug and Cosmetic Act (21 U.S.C. Section 355). For purposes of this section, no new drug shall be introduced or delivered for introduction except upon approval of an application pursuant to section 505 of the Federal Food, Drug and Cosmetic Act. ((36) amended February 11, 2000, P.L. 9, No. 3)
292641e71acad678(iii) Any material, compound, mixture, or preparation which contains any quantity of the
following hallucinogenic substances, their salts, isomers, and salts of isomers, unless
specifically excepted, whenever the existence of such salts, isomers, and salts of
isomers is possible within the specific chemical designation:
1. 3,4-methylenedioxy amphetamine.
2. 5-methoxy-3,4-methylenedioxy amphetamine.
3. 3,4,5-trimethoxy amphetamine.
4. Bufotenine.
5. Diethyltryptamine.
6. Dimethyltryptamine.
7. 4-methyl-2,5-dimethoxyamphetamine.
8. Ibogaine.
9. Lysergic acid diethylamide.
10. Mescaline.
11. Peyote.
12. N-ethyl-3-piperidyl benzilate.
13. N-methyl-3-piperidyl benzilate.
14. Psilocybin.
15. Psilocyn.
16. Tetrahydrocannabinols.
17. Salvia Divinorum.
18. Salvinorin A.
19. Divinorin A.
20. 3,4-Methylenedioxymethcathinone (Methylone).
21. 3,4-Methylenedioxypyrovalerone (MDPV).
22. 4-Methylmethcathinone (Mephedrone).
23. 4-Methoxymethcathinone.
24. 4-Fluoromethcathinone.
25. 3-Fluoromethcathinone.
26. 3,4-Methylenedioxymethamphetamine.
27. Methoxetamine.
((iii) amended June 8, 2016, P.L.258, No.37)Compound Laws, published by Compound Analytics, reports the record: statutes verbatim, official citations, enforcement facts and verification dates. Nothing here is legal advice and nothing here describes how to get around a law. A jurisdiction with no verified row is reported as not yet verified, never as legal. Found an error? Corrections policy.
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