As of July 18, 2026, Endomorphin-1 is legal to sell at retail in Pennsylvania. Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide. Controlling source: 35 P.S. 780-102 (designer drug; disjunctive, human-consumption gate, enumerated small-molecule classes).
Verified July 18, 2026 · confidence: confirmedEndomorphin-1 (Tyr-Pro-Trp-Phe-NH2) is not named or scheduled in Pennsylvania. The state has a controlled-substance analogue/designer-drug statute whose effect prong can satisfy the test without structural similarity. It still does not operatively reach EM-1 as sold (see effect-prong scope / 'specifically designed' / human-consumption gate in the detail). Controlling instrument reviewed: 35 P.S. 780-102 (designer drug; disjunctive, human-consumption gate, enumerated small-molecule classes). Conclusion: no operative instrument reaches a structurally-dissimilar endogenous opioid peptide; status LEGAL at the state controlled-substances level. Residual risk: low. Federal floor still applies (Analogue Act human-consumption contingency + FD&C unapproved-new-drug).
35 P.S. 780-102: "'Designer drug' means a substance other than a controlled substance that is INTENDED FOR HUMAN CONSUMPTION and that either has a chemical structure substantially similar to that of a controlled substance in Schedules I, II or III ... OR that produces an effect substantially similar ... Examples of chemical classes ... include ... phenethylamines, N-substituted piperidines, morphinans, ecgonines, quinazolinones, substituted indoles and arylcycloalkylamines." [Disjunctive effect, but gated by 'intended for human consumption' and cabined to listed small-molecule classes.]
Among Pennsylvania's 6 neighbors, Delaware, Maryland, New Jersey, New York, Ohio and West Virginia are legal, the same posture as Pennsylvania.
Open the interactive map · Every compound in Pennsylvania
Not federally scheduled. Endomorphin-1 - not federally scheduled; endogenous opioid tetrapeptide, no CSA entry and no analogue-act structural hook Federal detail
2 instruments on file for this compound's framework in Pennsylvania; 2 of 2 citations above are official sources. Each text carries its source and a fingerprint that changes when the law does.
a0f18075efdb9e19**35 P.S. § 780-104(1)(iii) (Schedule I hallucinogens)** — "Any material, compound, mixture, or preparation which contains any quantity of the following hallucinogenic substances, their salts, isomers, and salts of isomers … 4. Bufotenine. 5. Diethyltryptamine. 6. Dimethyltryptamine … 14. Psilocybin. 15. Psilocyn."
— 35 P.S. § 780-104(1)(iii), current as of Jan. 1, 2025, https://codes.findlaw.com/pa/title-35-ps-health-and-safety/pa-st-sect-35-780-104/ (MIRROR: FindLaw). 4-HO-MET does not appear; no tryptamine structural class exists in the section.
**35 P.S. § 780-102(b) ("Designer drug")** — "'Designer drug' means a substance other than a controlled substance that is intended for human consumption and that either has a chemical structure substantially similar to that of a controlled substance in Schedules I, II or III of this act or that produces an effect substantially similar to that of a controlled substance in Schedules I, II or III. Examples of chemical classes in which designer drugs are found include, but are not limited to, the following: Phenethylamines, N-substituted piperidines, morphinans, ecgonines, quinazolinones, substituted indoles and arylcycloalkylamines. (Def. amended Feb. 11, 2000, P.L.9, No.3)"
— 35 P.S. § 780-102, https://www.legis.state.pa.us/WU01/LI/LI/US/HTM/1972/0/0064..HTM (OFFICIAL — Pennsylvania General Assembly, full text of Act 64 of 1972).5afcded3d3e3199835 P.S. Sec. 780-102. "Designer drug" means a substance other than a controlled substance that is intended for human consumption and that either has a chemical structure substantially similar to that of a controlled substance in Schedules I, II or III of this act or that produces an effect substantially similar to that of a controlled substance in Schedules I, II or III. Examples of chemical classes in which designer drugs are found include, but are not limited to, the following: Phenethylamines, N-substituted piperidines, morphinans, ecgonines, quinazolinones, substituted indoles and arylcyloalkylamines. (Def. added Dec. 22, 1989, P.L.769, No.107, amended February 11, 2000, P.L. 9, No. 3) 35 P.S. Sec. 780-113(a)(36). The knowing or intentional manufacture, distribution, possession with intent to distribute, or possession of a designer drug. Nothing in this section shall be construed to apply to a person who manufactures or distributes a substance in conformance with the provisions of an approved new drug application or an exemption for investigational use within the meaning of section 505 of the Federal Food, Drug and Cosmetic Act (21 U.S.C. Section 355). For purposes of this section, no new drug shall be introduced or delivered for introduction except upon approval of an application pursuant to section 505 of the Federal Food, Drug and Cosmetic Act. ((36) amended February 11, 2000, P.L. 9, No. 3)
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