As of July 18, 2026, Endomorphin-1 is legal to sell at retail in Tennessee. Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide. Controlling source: TN Code 39-17-454 (controlled substance analogue; conjunctive, structure = near-identity <=2 atoms/1 group/1 bond).
Verified July 18, 2026 · confidence: confirmedEndomorphin-1 (Tyr-Pro-Trp-Phe-NH2) is not named or scheduled in Tennessee. The state has a controlled-substance analogue statute whose similarity test is CONJUNCTIVE (chemical structure substantially similar to a scheduled substance AND a substantially similar CNS effect). The structure prong fails for a tetrapeptide, so the statute does not reach EM-1. Controlling instrument reviewed: TN Code 39-17-454 (controlled substance analogue; conjunctive, structure = near-identity <=2 atoms/1 group/1 bond). Conclusion: no operative instrument reaches a structurally-dissimilar endogenous opioid peptide; status LEGAL at the state controlled-substances level. Residual risk: low. Federal floor still applies (Analogue Act human-consumption contingency + FD&C unapproved-new-drug).
TN Code 39-17-454: "'controlled substance analogue' means a ... substance ... that has the stimulant, depressant or hallucinogenic effect on the central nervous system of a controlled substance; AND (A) Has a chemical structure which is a derivative or structural analogue of the chemical structure of a controlled substance; provided, that ... 'analogue' means the structure of the tested item differs in no more than two (2) atoms, one (1) functional group, or one (1) double bond, from the structure of a controlled substance." [Conjunctive + near-identity structure test - impossible for a tetrapeptide.]
Among Tennessee's 8 neighbors, Alabama, Arkansas, Georgia, Kentucky, Mississippi, Missouri, North Carolina and Virginia are legal, the same posture as Tennessee.
Open the interactive map · Every compound in Tennessee
Not federally scheduled. Endomorphin-1 - not federally scheduled; endogenous opioid tetrapeptide, no CSA entry and no analogue-act structural hook Federal detail
2 instruments on file for this compound's framework in Tennessee; 2 of 2 citations above are official sources. Each text carries its source and a fingerprint that changes when the law does.
34473f1aa806770d(a)(1) As used in this section, "controlled substance analogue" means a capsule, pill, powder, product or other substance, however constituted, that has the stimulant, depressant or hallucinogenic effect on the central nervous system of a controlled substance; and (A) Has a chemical structure which is a derivative or structural analogue of the chemical structure of a controlled substance; provided, that as used in this subdivision (a)(1), "analogue" means the structure of the tested item differs in no more than two (2) atoms, one (1) functional group, or one (1) double bond, from the structure of a controlled substance; or (B) Is prohibited by Sec. 39-17-452. (2) "Controlled substance analogue" does not include: (A) A controlled substance; (B) Any substance for which there is an approved use or new drug application by the federal food and drug administration; (C) Any compound, mixture, or preparation that contains any controlled substance that is not for administration to a human being or animal, and that is packaged in such form or concentration, or with adulterants or denaturants, so that as packaged it does not present any significant potential for abuse; or (D) Any substance to which an investigational exemption applies under Sec. 505 of the Food, Drug and Cosmetic Act (21 U.S.C. Sec. 355), but only to the extent that conduct with respect to the substance is pursuant to such exemption. (c) It is an offense to knowingly manufacture, deliver, dispense or sell a controlled substance analogue or to possess a controlled substance analogue with the intent to manufacture, deliver, dispense or sell such substance. (d) It is an offense to knowingly possess or casually exchange a small amount of a controlled substance analogue not in excess of one (1) gram. (g)(1) A first violation of subsection (c) is a Class D felony. (2) A second or subsequent violation of subsection (c) is a Class C felony. (3) If the violation of subsection (c) involved the delivery, dispensing or sale of a controlled substance analogue to a minor, the person shall be punished one (1) classification higher than the punishment provided by this subsection (g) for delivering, dispensing or selling to an adult. (4) A violation of subsection (d) or (f) is a Class A misdemeanor.
8d0822600052fa33**§ 39-17-406(d) (hallucinogen chapeau)** — "Hallucinogenic substances, unless specifically excepted or unless listed in another schedule, means any material, compound mixture, or preparation that contains any quantity of the following hallucinogenic substances, or that contains any of its salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible within the specified chemical designation; provided, that for purposes of this subsection (d) only, 'isomer' includes the optical, positional, and geometric isomers:" — Tenn. Code Ann. § 39-17-406(d), https://law.justia.com/codes/tennessee/2021/title-39/chapter-17/part-4/section-39-17-406/ (MIRROR: Justia, 2021). 4-HO-MET is not listed; no tryptamine structural class exists in the section. **§ 39-17-454(a)(1) (controlled substance analogue)** — "'controlled substance analogue' means a capsule, pill, powder, product or other substance, however constituted, that has the stimulant, depressant or hallucinogenic effect on the central nervous system of a controlled substance; and (A) Has a chemical structure which is a derivative or structural analogue of the chemical structure of a controlled substance; provided, that as used in this subdivision (a)(1), 'analogue' means the structure of the tested item differs in no more than two (2) atoms, one (1) functional group, or one (1) double bond, from the structure of a controlled substance; or (B) Is prohibited by § 39-17-452." — Tenn. Code Ann. § 39-17-454(a)(1), https://law.justia.com/codes/tennessee/2021/title-39/chapter-17/part-4/section-39-17-454/ (MIRROR: Justia, 2021).
Compound Laws, published by Compound Analytics, reports the record: statutes verbatim, official citations, enforcement facts and verification dates. Nothing here is legal advice and nothing here describes how to get around a law. A jurisdiction with no verified row is reported as not yet verified, never as legal. Found an error? Corrections policy.
About · Methodology · Glossary · Changes · Data & API · llms.txt · Sitemap