Is Endomorphin-1 Legal in Iowa? (2026)

Rule type

permanent

Tier

unscheduled

What the record says

Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) is not named or scheduled in Iowa. The state has no controlled-substance analogue statute at all; designer drugs are reached only by specific scheduling. Controlling instrument reviewed: None general - simulated/imitation + fentanyl/cannabimimetic structural classes. Conclusion: no operative instrument reaches a structurally-dissimilar endogenous opioid peptide; status LEGAL at the state controlled-substances level. Residual risk: minimal. Federal floor still applies (Analogue Act human-consumption contingency + FD&C unapproved-new-drug).

Controlling language, verbatim

Iowa has no general structure/effect analogue statute. Iowa Code 124.101(27): "'Simulated controlled substance' means a substance which is not a controlled substance but which is expressly or impliedly represented to be a controlled substance ..." Schedule I reaches designer opioids only via enumerated structural classes (e.g., 124.204(9) fentanyl-related substances). [Representation + specific structural classes only.]

Source of excerpt

Citations

1. Iowa Code 124.101(20) (opiate def) (Iowa Legislature) PRIMARYOFFICIAL
2. Iowa Code 124.101(20) (opiate def) (Iowa Legislature)OFFICIAL

Where Endomorphin-1 stands across the country

Among Iowa's 6 neighbors, Illinois, Minnesota, Missouri, Nebraska, South Dakota and Wisconsin are legal, the same posture as Iowa.

Open the interactive map · Every compound in Iowa

Federal posture

Not federally scheduled. Endomorphin-1 - not federally scheduled; endogenous opioid tetrapeptide, no CSA entry and no analogue-act structural hook Federal detail

Verbatim law on file for Iowa

1 instrument on file for this compound's framework in Iowa; 2 of 2 citations above are official sources. Each text carries its source and a fingerprint that changes when the law does.

**§ 124.204(4):** "Hallucinogenic substances. … any material, compound, mixture, or preparation, which contains any quantity of the following hallucinogenic substances, or which contains any of its salts, isomers, and salts of isomers … (for purposes of this subsection only, the term 'isomer' includes the optical, position and geometric isomers): … bufotenine; … diethyltryptamine; … dimethyltryptamine; … psilocybin; … psilocyn; … alpha-ethyltryptamine; … 5-MeO-DIPT; … alpha-methyltryptamine; … 5-methoxy-N,N-dimethyltryptamine." (4-HO-MET not listed; isomer-only catch-all does not reach a homolog.)
— Iowa Code § 124.204(4), official Iowa Legislature: https://www.legis.iowa.gov/docs/code/124.204.pdf
**Scope of prohibited acts — § 124.401:** reaches only "a controlled substance, a counterfeit substance, a simulated controlled substance, or an imitation controlled substance." The only "analog" hooks are narrow — "analogs of methamphetamine" and "analogs of ephedrine … pseudoephedrine." Neither reaches a tryptamine.
— Iowa Code § 124.401, official: https://www.legis.iowa.gov/docs/code/124.401.pdf

Related

Endomorphin-1 in neighboring states

• Endomorphin-1 in Illinois Legal
• Endomorphin-1 in Minnesota Legal
• Endomorphin-1 in Missouri Legal
• Endomorphin-1 in Nebraska Legal
• Endomorphin-1 in South Dakota Legal
• Endomorphin-1 in Wisconsin Legal

Endomorphin-1 in other states

Same framework in Iowa

• 4-HO-MET (Metocin) in Iowa Legal
• 5-MAPB in Iowa Legal
• Blue Lotus (Nymphaea caerulea) in Iowa Legal
• Amanita muscaria / Muscimol in Iowa Legal

Other compounds in Iowa

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