Is Endomorphin-1 Legal in New York? (2026)

Rule type

permanent

Tier

unscheduled

What the record says

Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) is not named or scheduled in New York. The state has no general analogue statute; the only analogue reach is a fentanyl-structure test that cannot capture a non-fentanyl peptide. Controlling instrument reviewed: None general - fentanyl-analogue (structural) only. Conclusion: no operative instrument reaches a structurally-dissimilar endogenous opioid peptide; status LEGAL at the state controlled-substances level. Residual risk: minimal. Federal floor still applies (Analogue Act human-consumption contingency + FD&C unapproved-new-drug).

Controlling language, verbatim

N.Y. Pub. Health Law 3306 (Sch I opiates) reaches "opium and opiate, and any salt, compound, derivative, or preparation of opium or opiate" plus enumerated synthetics; New York has no general analogue statute - its only analogue reach is for fentanyl analogues, defined by structural modification of fentanyl. [No general analogue reach; a peptide is not a fentanyl analogue.]

Source of excerpt

Citations

1. None general - fentanyl-analogue (structural) only (New York Legislature) PRIMARYOFFICIAL
2. N.Y. Pub. Health Law 3302/3306 (Sch I opiates) (New York Legislature)OFFICIAL

Where Endomorphin-1 stands across the country

Among New York's 5 neighbors, Connecticut, Massachusetts, New Jersey, Pennsylvania and Vermont are legal, the same posture as New York.

Open the interactive map · Every compound in New York

Federal posture

Not federally scheduled. Endomorphin-1 - not federally scheduled; endogenous opioid tetrapeptide, no CSA entry and no analogue-act structural hook Federal detail

Verbatim law on file for New York

1 instrument on file for this compound's framework in New York; 2 of 2 citations above are official sources. Each text carries its source and a fingerprint that changes when the law does.

**PHL § 3306, Schedule I(d) (hallucinogen chapeau)** — "Hallucinogenic substances. Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation, which contains any quantity of the following hallucinogenic substances, or which contains any of its salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible within the specific chemical designation (for purposes of this paragraph only, the term 'isomer' includes the optical, position and geometric isomers): … (18) Psilocybin. (19) Psilocyn."
— N.Y. Pub. Health Law § 3306, Sch. I(d)(18)–(19), https://law.justia.com/codes/new-york/pbh/article-33/title-1/3306/ (MIRROR: Justia). The qualifier is "isomers" only (optical/position/geometric); no homologue extension, so the N-ethyl homolog 4-HO-MET is not captured.
**PHL § 3302(4) (definitions — no analog provision)** — "'Controlled substance' means a substance or substances listed in section thirty-three hundred six of this title." PHL 3302's 41 definitions contain no "analog," "analogue," or "substantially similar in chemical structure" provision.
— N.Y. Pub. Health Law § 3302(4), https://law.justia.com/codes/new-york/pbh/article-33/title-1/3302/ (MIRROR: Justia).

Related

Endomorphin-1 in neighboring states

• Endomorphin-1 in Connecticut Legal
• Endomorphin-1 in Massachusetts Legal
• Endomorphin-1 in New Jersey Legal
• Endomorphin-1 in Pennsylvania Legal
• Endomorphin-1 in Vermont Legal

Endomorphin-1 in other states

Same framework in New York

• 4-HO-MET (Metocin) in New York Legal
• 5-MAPB in New York Legal
• Blue Lotus (Nymphaea caerulea) in New York Legal
• Amanita muscaria / Muscimol in New York Legal

Other compounds in New York

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