As of July 18, 2026, Endomorphin-1 is legal to sell at retail in South Carolina. Unscheduled; analog effect-prong reaches analgesics - human-consumption gate is the SOLE barrier (moderate residual risk). Controlling source: S.C. Code 44-53-110(7) (controlled substance analogue; effect prong INCLUDES 'analgesic'; human-consumption gate is the SOLE barrier).
Verified July 18, 2026 · confidence: confirmedEndomorphin-1 (Tyr-Pro-Trp-Phe-NH2) is not named or scheduled in South Carolina. The state has a controlled-substance analogue/designer-drug statute whose effect prong can satisfy the test without structural similarity. It still does not operatively reach EM-1 as sold (see effect-prong scope / 'specifically designed' / human-consumption gate in the detail). Controlling instrument reviewed: S.C. Code 44-53-110(7) (controlled substance analogue; effect prong INCLUDES 'analgesic'; human-consumption gate is the SOLE barrier). Conclusion: no operative instrument reaches a structurally-dissimilar endogenous opioid peptide; status LEGAL at the state controlled-substances level. Residual risk: moderate. Federal floor still applies (Analogue Act human-consumption contingency + FD&C unapproved-new-drug).
S.C. Code 44-53-110(7): "'Controlled substance analogue' means a substance that is INTENDED FOR HUMAN CONSUMPTION and that either has a chemical structure substantially similar to that of a controlled substance in Schedules I, II, or III OR has a stimulant, depressant, ANALGESIC, or hallucinogenic effect on the central nervous system that is substantially similar to that of a controlled substance in Schedules I, II, or III. Controlled substance analogue does not include ... any substance for which there is an approved new drug application; or ... any substance if an exemption is in effect for investigational use ..." [Disjunctive; effect prong includes 'analgesic'; SOLE barrier is the front-end 'intended for human consumption' gate - closest call in the country.]
Among South Carolina's 2 neighbors, Georgia and North Carolina are legal, the same posture as South Carolina.
Open the interactive map · Every compound in South Carolina
Not federally scheduled. Endomorphin-1 - not federally scheduled; endogenous opioid tetrapeptide, no CSA entry and no analogue-act structural hook Federal detail
2 instruments on file for this compound's framework in South Carolina; 2 of 2 citations above are official sources. Each text carries its source and a fingerprint that changes when the law does.
2ac96b8e28ca164c**§ 44-53-190(D) (hallucinogen chapeau)** — "(D) Any material, compound, mixture, or preparation which contains any quantity of the following hallucinogenic substances, their salts, isomers, and salts of isomers, unless specifically excepted, whenever the existence of such salts, isomers, and salts of isomers is possible within the specific chemical designation:" — S.C. Code § 44-53-190(D), https://www.scstatehouse.gov/code/t44c053.php (OFFICIAL — SC Legislature). The enumerated tryptamines are Bufotenine, DET, DMT, Psilocybin, Psilocyn only; 4-HO-MET is not present, and no tryptamine structural class exists in § 44-53-190. **§ 44-53-110(7) (controlled substance analogue)** — "'Controlled substance analogue' means a substance that is intended for human consumption and that either has a chemical structure substantially similar to that of a controlled substance in Schedules I, II, or III or has a stimulant, depressant, analgesic, or hallucinogenic effect on the central nervous system that is substantially similar to that of a controlled substance in Schedules I, II, or III." — S.C. Code § 44-53-110(7), https://law.justia.com/codes/south-carolina/2022/title-44/chapter-53/section-44-53-110/ (MIRROR: Justia; canonical version identical).
fcee94a41f3ee741S.C. Code Ann. Section 44-53-110(7): (7) "Controlled substance analogue" means a substance that is intended for human consumption and that either has a chemical structure substantially similar to that of a controlled substance in Schedules I, II, or III or has a stimulant, depressant, analgesic, or hallucinogenic effect on the central nervous system that is substantially similar to that of a controlled substance in Schedules I, II, or III. Controlled substance analogue does not include a controlled substance; any substance generally recognized as safe and effective within the meaning of the Federal Food, Drug and Cosmetic Act, 21 U.S.C. 301 et seq.; any substance for which there is an approved new drug application; or, with respect to a particular person, any substance if an exemption is in effect for investigational use for that person under Section 505 of the Federal Food, Drug and Cosmetic Act, 21 U.S.C. 355. S.C. Code Ann. Section 44-53-370(a): Except as authorized by this article it shall be unlawful for any person: (1) to manufacture, distribute, dispense, deliver, purchase, aid, abet, attempt, or conspire to manufacture, distribute, dispense, deliver, or purchase, or possess with the intent to manufacture, distribute, dispense, deliver, or purchase a controlled substance or a controlled substance analogue;
Compound Laws, published by Compound Analytics, reports the record: statutes verbatim, official citations, enforcement facts and verification dates. Nothing here is legal advice and nothing here describes how to get around a law. A jurisdiction with no verified row is reported as not yet verified, never as legal. Found an error? Corrections policy.
About · Methodology · Glossary · Changes · Data & API · llms.txt · Sitemap