Is Mitragynine Pseudoindoxyl Legal in South Carolina? (2026)

Federal

Pseudoindoxyl -- federally Schedule I (DEA temporary order, drug code 9672, eff. 2026-08-26) (effective 2026-08-26). State-law reading underneath: Restricted.

Rule type

permanent

Tier

kcpa regulated

Effective

2025-07-11

What the record says

No concentration cap in SC; only FULLY synthetic alkaloids are banned (44-53-2020(A)(2)(c)). A non-fully-synthetic, labeled pseudoindoxyl is subject only to age/labeling.

Controlling language, verbatim

It is unlawful for a kratom processor or kratom retailer to ... (2) ... sell any kratom product that: ... (c) contains a fully synthetic alkaloid including, but not limited to, fully synthetic mitragynine, fully synthetic 7-hydroxymitragynine, or any other fully synthetically derived compound of the plant mitragyna speciosa; ... (e) does not meet the labeling requirements ... (S.C. Code 44-53-2020(A))

Source of excerpt

Citations

No citation on file for this row yet.

Where Mitragynine Pseudoindoxyl stands across the country

Among South Carolina's 2 neighbors, Georgia and North Carolina are illegal, the same posture as South Carolina.

Open the interactive map · Every compound in South Carolina

Federal posture

Federally scheduled or prohibited. Pseudoindoxyl -- federally Schedule I (DEA temporary order, drug code 9672, eff. 2026-08-26) Federal detail

Pending deadlines

• 2026-08-01 · Federal · DEA temporary Schedule I order for mitragynine pseudoindoxyl, MGM-15, MGM-16 - effective on Federal Register publication (DEA NOI 2026-07-01)
• 2026-08-05 · Federal · DEA temporary Schedule I - mitragynine pseudoindoxyl, MGM-15, MGM-16 (DEA-1644 / FR 2026-17429)
  Second DEA Notice of Intent filed with the Federal Register on 7/1/2026 (companion to the 7-OH NOI, DEA-1570), placing three 7-OH-RELATED substances — mitragynine pseudoindoxyl (MP), MGM-15, and MGM-16 — into Schedule I under 21 U.S.C. 811(h). HHS confirmed these have no accepted medical use and a high potential for abuse. Same procedural clock as the 7-OH NOI: 30-day notice period, temporary order cannot issue before ~2026-08-05, effective on Federal Register publication of the order, 2-year duration (+1 yr possible). Unlike the 7-OH NOI there is NO concentration threshold here — these named substances are controlled outright. Confirm the exact companion docket number when the Federal Register posts on 7/6/2026.
• 2026-11-13 · Federal · DEA to replace pseudoindoxyl Schedule I order with a threshold order (re-notice) (DEA-1570 / FR 2026-20943)
  On or after Nov 13, 2026 DEA intends to withdraw the Aug 26 order (FR 2026-17429) and place pseudoindoxyl in Schedule I only above a threshold: more than 1 mg/g or 1 mg/mL alone or combined with 7-OH, or mitragynine under 100 times the pseudoindoxyl or combined amount. Until then it stays Schedule I at any amount. MGM-15 and MGM-16 stay Schedule I unchanged (FR 2026-20942).

Verbatim law on file for South Carolina

1 instrument on file for this compound's framework in South Carolina; 0 of 0 citations above are official sources. Each text carries its source and a fingerprint that changes when the law does.

44-53-2010 Definitions. (3) "Kratom" means any part of the tropical evergreen plant mitragyna speciosa. (5) "Kratom product" means any food or dietary ingredient ... that: (a) contains any part of the leaf of the plant mitragyna speciosa, either on its native leaf or extracted form; or (b) contains any kratom alkaloids or constituents, or synthesized metabolites of any kratom alkaloids or constituents.
44-53-2020 (A) It is unlawful for a kratom processor or kratom retailer to: (1) distribute, dispense, or sell any kratom product to any individual under twenty-one years of age; or (2) prepare, manufacture, distribute, dispense, or sell any kratom product that: (a) is adulterated with a dangerous non-kratom substance ...; (b) contains a poisonous or otherwise harmful non-kratom ingredient including ... any substance listed in Section 44-53-190, 210, 230, 250, or 270; (c) contains a fully synthetic alkaloid including, but not limited to, fully synthetic mitragynine, fully synthetic 7-hydroxymitragynine, or any other fully synthetically derived compound of the plant mitragyna speciosa; (d) [residual solvents > USP-NF]; or (e) [not properly labeled]. (B) [no display accessible to under-21].
44-53-2030 Labels (ingredients; amount of mitragynine and 7-hydroxymitragynine; serving size; servings per container; vendor; precautionary statements; not-intended-to-treat; under-21 prohibition).
44-53-2040 Violations: civil penalty up to $1,000 first / $2,000 subsequent.

Related

Mitragynine Pseudoindoxyl in neighboring states

• Mitragynine Pseudoindoxyl in Georgia Illegal
• Mitragynine Pseudoindoxyl in North Carolina Illegal

Mitragynine Pseudoindoxyl in other states

Same framework in South Carolina

• 7-OH (7-Hydroxymitragynine) in South Carolina Restricted
• Kratom (Whole Leaf / Mitragynine) in South Carolina Restricted
• Speciociliatine in South Carolina Restricted

Other compounds in South Carolina

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