Is Endomorphin-1 Legal in Minnesota? (2026)

Rule type

permanent

Tier

unscheduled

What the record says

Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) is not named or scheduled in Minnesota. The state has a controlled-substance analogue statute whose similarity test is CONJUNCTIVE (chemical structure substantially similar to a scheduled substance AND a substantially similar CNS effect). The structure prong fails for a tetrapeptide, so the statute does not reach EM-1. Controlling instrument reviewed: Minn. Stat. 152.01 subd. 23 (analog). Conclusion: no operative instrument reaches a structurally-dissimilar endogenous opioid peptide; status LEGAL at the state controlled-substances level. Residual risk: minimal. Federal floor still applies (Analogue Act human-consumption contingency + FD&C unapproved-new-drug).

Controlling language, verbatim

Minn. Stat. 152.01 subd. 23: "'analog' means a substance, the chemical structure of which is substantially similar to the chemical structure of a controlled substance in Schedule I or II: (1) that has a stimulant, depressant, or hallucinogenic effect on the central nervous system that is substantially similar to or greater than" a Schedule I/II substance. [Conjunctive - structure prong fails.]

Source of excerpt

Citations

1. Minn. Stat. 152.01 subd. 23 (analog) (Minnesota Legislature) PRIMARYOFFICIAL
2. Minn. Stat. 152.01 subd. 11 (opiate def) (Minnesota Legislature)OFFICIAL

Where Endomorphin-1 stands across the country

Among Minnesota's 4 neighbors, Iowa, North Dakota, South Dakota and Wisconsin are legal, the same posture as Minnesota.

Open the interactive map · Every compound in Minnesota

Federal posture

Not federally scheduled. Endomorphin-1 - not federally scheduled; endogenous opioid tetrapeptide, no CSA entry and no analogue-act structural hook Federal detail

Verbatim law on file for Minnesota

2 instruments on file for this compound's framework in Minnesota; 2 of 2 citations above are official sources. Each text carries its source and a fingerprint that changes when the law does.

**Class lead-in — § 152.02 subd. 2(d):** "Hallucinogens. Any material, compound, mixture or preparation which contains any quantity of the following substances, **their analogs**, salts, isomers (whether optical, positional, or geometric), and salts of isomers, unless specifically excepted or unless listed in another schedule, whenever the existence of the analogs, salts, isomers, and salts of isomers is possible:"
— Minn. Stat. § 152.02 subd. 2(d), official MN Revisor: https://www.revisor.mn.gov/statutes/cite/152.02
**Named anchors that 4-HO-MET is an analog/homolog of:** "(22) psilocyn; … (44) 4-hydroxy-N-methyl-N-propyltryptamine (4-HO-MPT); … (47) 4-hydroxy-N,N-diisopropyltryptamine (4-HO-DiPT); … (72) 3-(2-Ethyl(methyl)aminoethyl)-1H-indol-4-yl (4-AcO-MET); and …"
— Minn. Stat. § 152.02 subd. 2(d)(22),(44),(47),(72), same official URL. (4-AcO-MET is the named acetoxy prodrug of 4-HO-MET; 4-HO-MET is its active metabolite and an "analog" of the listed 4-hydroxytryptamines.)

(i) A controlled substance analog, to the extent that it is implicitly or explicitly intended for human consumption.

Related

Endomorphin-1 in neighboring states

• Endomorphin-1 in Iowa Legal
• Endomorphin-1 in North Dakota Legal
• Endomorphin-1 in South Dakota Legal
• Endomorphin-1 in Wisconsin Legal

Endomorphin-1 in other states

Same framework in Minnesota

• 4-HO-MET (Metocin) in Minnesota Illegal
• 5-MAPB in Minnesota Gray area
• Blue Lotus (Nymphaea caerulea) in Minnesota Legal
• Amanita muscaria / Muscimol in Minnesota Legal

Other compounds in Minnesota

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