As of July 18, 2026, Endomorphin-1 is legal to sell at retail in Kentucky. Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide. Controlling source: KRS 218A.010(9) (controlled substance analogue).
Verified July 18, 2026 · confidence: confirmedEndomorphin-1 (Tyr-Pro-Trp-Phe-NH2) is not named or scheduled in Kentucky. The state has a controlled-substance analogue statute whose similarity test is CONJUNCTIVE (chemical structure substantially similar to a scheduled substance AND a substantially similar CNS effect). The structure prong fails for a tetrapeptide, so the statute does not reach EM-1. Controlling instrument reviewed: KRS 218A.010(9) (controlled substance analogue). Conclusion: no operative instrument reaches a structurally-dissimilar endogenous opioid peptide; status LEGAL at the state controlled-substances level. Residual risk: minimal. Federal floor still applies (Analogue Act human-consumption contingency + FD&C unapproved-new-drug).
KRS 218A.010(9)(a): "'Controlled substance analogue' ... means a substance: 1. The chemical structure of which is substantially similar to the structure of a controlled substance in Schedule I or II; AND 2. Which has a stimulant, depressant, or hallucinogenic effect on the central nervous system that is substantially similar to or greater than ...; or 3. ... which such person represents or intends ..." (b) excludes approved-new-drug / investigational / not-for-human-consumption substances. [Conjunctive - structure prong fails.]
Among Kentucky's 7 neighbors, Illinois, Indiana, Missouri, Ohio, Tennessee, Virginia and West Virginia are legal, the same posture as Kentucky.
Open the interactive map · Every compound in Kentucky
Not federally scheduled. Endomorphin-1 - not federally scheduled; endogenous opioid tetrapeptide, no CSA entry and no analogue-act structural hook Federal detail
2 instruments on file for this compound's framework in Kentucky; 2 of 2 citations above are official sources. Each text carries its source and a fingerprint that changes when the law does.
584940202b9d4357**Schedule mechanism — 902 KAR 55:015 § 1:** "Each substance that is scheduled or designated as a Schedule I controlled substance under 21 C.F.R. 1308.11 … shall be scheduled or designated at the state level as a Schedule I controlled substance." (Kentucky lists no individual state tryptamines; the question collapses to the federal list, which does not name 4-HO-MET.) — 902 KAR 55:015 § 1: https://apps.legislature.ky.gov/law/kar/titles/902/055/015/9121/ **Analog act — KRS 218A.010(7):** "'Controlled substance analogue,' except as provided in paragraph (b) … means a substance: 1. The chemical structure of which is substantially similar to the structure of a controlled substance in Schedule I or II; and 2. Which has a stimulant, depressant, or hallucinogenic effect on the central nervous system that is substantially similar to or greater than … a controlled substance in Schedule I or II; or 3. With respect to a particular person, which such person represents or intends to have [such effect] …" And **KRS 218A.010(6):** "'Controlled substance' means … a drug, substance, or immediate precursor in Schedules I through V and includes a controlled substance analogue." — KRS 218A.010(6)–(7); via labeled Justia mirror, cross-checked against current FindLaw (identical): https://law.justia.com/codes/kentucky/2014/chapter-218a/section-218a.010/
9e787874586183ca(8) 'Controlled substance' means methamphetamine, or a drug, substance, or immediate precursor in Schedules I through V and includes a controlled substance analogue; (9)(a) 'Controlled substance analogue,' except as provided in paragraph (b) of this subsection, means a substance: 1. The chemical structure of which is substantially similar to the structure of a controlled substance in Schedule I or II; and 2. Which has a stimulant, depressant, or hallucinogenic effect on the central nervous system that is substantially similar to or greater than the stimulant, depressant, or hallucinogenic effect on the central nervous system of a controlled substance in Schedule I or II; or 3. With respect to a particular person, which such person represents or intends to have a stimulant, depressant, or hallucinogenic effect on the central nervous system that is substantially similar to or greater than the stimulant, depressant, or hallucinogenic effect on the central nervous system of a controlled substance in Schedule I or II. (b) Such term does not include: 1. Any substance for which there is an approved new drug application; 2. With respect to a particular person, any substance if an exemption is in effect for investigational use for that person pursuant to federal law to the extent conduct with respect to such substance is pursuant to such exemption; or 3. Any substance to the extent not intended for human consumption before the exemption described in subparagraph 2. of this paragraph takes effect with respect to that substance;
Compound Laws, published by Compound Analytics, reports the record: statutes verbatim, official citations, enforcement facts and verification dates. Nothing here is legal advice and nothing here describes how to get around a law. A jurisdiction with no verified row is reported as not yet verified, never as legal. Found an error? Corrections policy.
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