Is Endomorphin-1 Legal in Florida? (2026)

Legal

As of October 7, 2026, Endomorphin-1 is legal to sell at retail in Florida. Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide. Controlling source: Fla. Stat. 893.0356 (controlled substance analog).

Verified October 7, 2026 (manual) · confidence: confirmed
Rule type
permanent
Tier
unscheduled

What the record says

Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) is not named or scheduled in Florida. The state has a controlled-substance analogue statute whose similarity test is CONJUNCTIVE (chemical structure substantially similar to a scheduled substance AND a substantially similar CNS effect). The structure prong fails for a tetrapeptide, so the statute does not reach EM-1. Controlling instrument reviewed: Fla. Stat. 893.0356 (controlled substance analog). Conclusion: no operative instrument reaches a structurally-dissimilar endogenous opioid peptide; status LEGAL at the state controlled-substances level. Residual risk: minimal. Federal floor still applies (Analogue Act human-consumption contingency + FD&C unapproved-new-drug).

Controlling language, verbatim

Fla. Stat. 893.0356: "'[C]ontrolled substance analog' means a substance ... [that] is substantially similar to that of a controlled substance listed in Schedule I or Schedule II AND ... [h]as a stimulant, depressant, or hallucinogenic effect on the central nervous system ... substantially similar to or greater than" a Schedule I/II substance. ('Substantially similar' = single-atom/functional-group difference.) [Conjunctive - structure prong fails.]

Source of excerpt

Citations

  1. Fla. Stat. 893.0356 (controlled substance analog) (Florida Legislature) PRIMARYOFFICIAL
  2. Fla. Stat. 893.02 (opiate/opioid def) (Florida Legislature)OFFICIAL

Where Endomorphin-1 stands across the country

LegalRestrictedGray areaIllegalNot yet verified

Among Florida's 2 neighbors, Alabama and Georgia are legal, the same posture as Florida.

Open the interactive map · Every compound in Florida

Federal posture

Not federally scheduled. Endomorphin-1 - not federally scheduled; endogenous opioid tetrapeptide, no CSA entry and no analogue-act structural hook Federal detail

Verbatim law on file for Florida

2 instruments on file for this compound's framework in Florida; 2 of 2 citations above are official sources. Each text carries its source and a fingerprint that changes when the law does.

Fla. Stat. § 893.03(1)(c) — Schedule I; item 194 ("Substituted Tryptamines"), with 4-HO-MET as a named sub-entry.OFFICIAL
Instrument
statute
Source
https://www.flsenate.gov/Laws/Statutes/2025/893.03
Retrieved
2026-06-19
Fingerprint
94b008015bc58e97
**Named entry** — "x. 4-Hydroxy-MET (4-Hydroxy-N-methyl-N-ethyltryptamine)."
— Fla. Stat. § 893.03(1)(c)194., https://www.flsenate.gov/Laws/Statutes/2025/893.03 (official Florida Senate, 2025 Florida Statutes)
**Class catch-all** — "194. Substituted Tryptamines.—Unless specifically excepted or unless listed in another schedule, or contained within a pharmaceutical product approved by the United States Food and Drug Administration, any material, compound, mixture, or preparation containing a 2-(1H-indol-3-yl)ethanamine, for example tryptamine, structure with or without mono- or di-substitution of the amine nitrogen with alkyl or alkenyl groups, or by inclusion of the amino nitrogen atom in a cyclic structure, whether or not substituted at the alpha position with an alkyl group, whether or not substituted on the indole ring to any extent with any alkyl, alkoxy, halo, hydroxyl, or acetoxy groups, including, but not limited to: …"
— Fla. Stat. § 893.03(1)(c)194., same URL
Fla. Stat. Sec. 893.03(1)(c)192 · Schedule I - Substituted Phenethylamines (including 5-MAPB at sub-subparagraph oo.)OFFICIAL
Instrument
Schedule I - Substituted Phenethylamines (including 5-MAPB at sub-subparagraph oo.)
Source
https://www.flsenate.gov/Laws/Statutes/2024/Chapter893/All
Retrieved
2026-07-20
Fingerprint
8620c99cca2dd898
192. Substituted Phenethylamines.-Unless specifically excepted or unless listed in another schedule, or contained within a pharmaceutical product approved by the United States Food and Drug Administration, any material, compound, mixture, or preparation, including its salts, isomers, esters, or ethers, and salts of isomers, esters, or ethers, whenever the existence of such salts is possible within any of the following specific chemical designations, any compound containing a phenethylamine structure, without a beta-keto group, and without a benzyl group attached to the amine group, whether or not the compound is further modified with or without substitution on the phenyl ring to any extent with alkyl, alkylthio, nitro, alkoxy, thio, halide, fused alkylenedioxy, fused furan, fused benzofuran, fused dihydrofuran, or fused tetrahydropyran substituents, whether or not further substituted on a ring to any extent, with or without substitution at the alpha or beta position by any alkyl substituent, with or without substitution at the nitrogen atom, and with or without inclusion of the 2-amino nitrogen atom in a cyclic structure, including, but not limited to: a. 2C-B (4-Bromo-2,5-dimethoxyphenethylamine). b. 2C-E (4-Ethyl-2,5-dimethoxyphenethylamine). c. 2C-T-4 (4-Isopropylthio-2,5-dimethoxyphenethylamine). d. 2C-C (4-Chloro-2,5-dimethoxyphenethylamine). e. 2C-T (4-Methylthio-2,5-dimethoxyphenethylamine). f. 2C-T-2 (4-Ethylthio-2,5-dimethoxyphenethylamine). g. 2C-T-7 (4-(n)-Propylthio-2,5-dimethoxyphenethylamine). h. 2C-I (4-Iodo-2,5-dimethoxyphenethylamine). i. 2C-D (4-Methyl-2,5-dimethoxyphenethylamine). j. 2C-H (2,5-Dimethoxyphenethylamine). k. 2C-N (4-Nitro-2,5-dimethoxyphenethylamine). l. 2C-P (4-(n)-Propyl-2,5-dimethoxyphenethylamine). m. MDMA (3,4-Methylenedioxymethamphetamine). n. MBDB (Methylbenzodioxolylbutanamine) or (3,4-Methylenedioxy-N-methylbutanamine). o. MDA (3,4-Methylenedioxyamphetamine). p. 2,5-Dimethoxyamphetamine. q. Fluoroamphetamine. r. Fluoromethamphetamine. s. MDEA (3,4-Methylenedioxy-N-ethylamphetamine). t. DOB (4-Bromo-2,5-dimethoxyamphetamine). u. DOC (4-Chloro-2,5-dimethoxyamphetamine). v. DOET (4-Ethyl-2,5-dimethoxyamphetamine). w. DOI (4-Iodo-2,5-dimethoxyamphetamine). x. DOM (4-Methyl-2,5-dimethoxyamphetamine). y. PMA (4-Methoxyamphetamine). z. N-Ethylamphetamine. aa. 3,4-Methylenedioxy-N-hydroxyamphetamine. bb. 5-Methoxy-3,4-methylenedioxyamphetamine. cc. PMMA (4-Methoxymethamphetamine). dd. N,N-Dimethylamphetamine. ee. 3,4,5-Trimethoxyamphetamine. ff. 4-APB (4-(2-Aminopropyl)benzofuran). gg. 5-APB (5-(2-Aminopropyl)benzofuran). hh. 6-APB (6-(2-Aminopropyl)benzofuran). ii. 7-APB (7-(2-Aminopropyl)benzofuran). jj. 4-APDB (4-(2-Aminopropyl)-2,3-dihydrobenzofuran). kk. 5-APDB (5-(2-Aminopropyl)-2,3-dihydrobenzofuran). ll. 6-APDB (6-(2-Aminopropyl)-2,3-dihydrobenzofuran). mm. 7-APDB (7-(2-Aminopropyl)-2,3-dihydrobenzofuran). nn. 4-MAPB (4-(2-Methylaminopropyl)benzofuran). oo. 5-MAPB (5-(2-Methylaminopropyl)benzofuran). pp. 6-MAPB (6-(2-Methylaminopropyl)benzofuran). qq. 7-MAPB (7-(2-Methylaminopropyl)benzofuran). rr. 5-EAPB (5-(2-Ethylaminopropyl)benzofuran). ss. 5-MAPDB (5-(2-Methylaminopropyl)-2,3-dihydrobenzofuran), which does not include phenethylamine, mescaline as described in subparagraph 20., substituted cathinones as described in subparagraph 191., N-Benzyl phenethylamine compounds as described in subparagraph 193., or methamphetamine as described in subparagraph (2)(c)5.

Related

Endomorphin-1 in neighboring states

Endomorphin-1 in other states

Same framework in Florida

Other compounds in Florida

Cite this page

Compound Analytics. "Is Endomorphin-1 Legal in Florida? (2026)." Compound Laws, https://compoundlaws.com/compounds/endomorphin-1/florida/. Accessed October 25, 2026.

Compound Laws, published by Compound Analytics, reports the record: statutes verbatim, official citations, enforcement facts and verification dates. Nothing here is legal advice and nothing here describes how to get around a law. A jurisdiction with no verified row is reported as not yet verified, never as legal. Found an error? Corrections policy.

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