Is Endomorphin-1 Legal in Virginia? (2026)

Rule type

permanent

Tier

unscheduled

What the record says

Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) is not named or scheduled in Virginia. The state has a controlled-substance analogue statute whose similarity test is CONJUNCTIVE (chemical structure substantially similar to a scheduled substance AND a substantially similar CNS effect). The structure prong fails for a tetrapeptide, so the statute does not reach EM-1. Controlling instrument reviewed: VA Code 54.1-3401 (controlled substance analog; conjunctive; operative only once Board schedules). Conclusion: no operative instrument reaches a structurally-dissimilar endogenous opioid peptide; status LEGAL at the state controlled-substances level. Residual risk: minimal. Federal floor still applies (Analogue Act human-consumption contingency + FD&C unapproved-new-drug).

Controlling language, verbatim

VA Code 54.1-3401: "'Controlled substance analog' means a substance the chemical structure of which is substantially similar to the chemical structure of a controlled substance in Schedule I or II AND either (i) which has a stimulant, depressant, or hallucinogenic effect on the central nervous system that is substantially similar to or greater than [that] of a controlled substance in Schedule I or II or (ii) ... which [a person] represents or intends to have [such] effect ..." (operative only once the Board schedules the analog under 54.1-3443(D)). [Conjunctive; structure prong fails; also requires Board action.]

Source of excerpt

Citations

1. VA Code 54.1-3401 (controlled substance analog; conjunctive; operative only once Board schedules) (Virginia Legislature) PRIMARYOFFICIAL
2. VA Code 54.1-3401 (opiate def) (Virginia Legislature)OFFICIAL

Where Endomorphin-1 stands across the country

Among Virginia's 6 neighbors, District of Columbia, Kentucky, Maryland, North Carolina, Tennessee and West Virginia are legal, the same posture as Virginia.

Open the interactive map · Every compound in Virginia

Federal posture

Not federally scheduled. Endomorphin-1 - not federally scheduled; endogenous opioid tetrapeptide, no CSA entry and no analogue-act structural hook Federal detail

Verbatim law on file for Virginia

2 instruments on file for this compound's framework in Virginia; 2 of 2 citations above are official sources. Each text carries its source and a fingerprint that changes when the law does.

**§ 54.1-3446(3)** "Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation, which contains any quantity of the following hallucinogenic substances, or which contains any of its salts, isomers, and salts of isomers, whenever the existence of such salts, isomers, and salts of isomers is possible within the specific chemical designation (for purposes of this subdivision only, the term 'isomer' includes the optical, position, and geometric isomers): … **4-hydroxy-N-methyl-N-ethyltryptamine (other names: 4-hydroxy MET, Metocin)** …"
— Va. Code § 54.1-3446(3), https://law.lis.virginia.gov/vacode/title54.1/chapter34/section54.1-3446/ (official Virginia LIS; psilocybin and psilocyn are separately listed in the same subdivision)

Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation, which contains any quantity of the following hallucinogenic substances, or which contains any of its salts, isomers, and salts of isomers, whenever the existence of such salts, isomers, and salts of isomers is possible within the specific chemical designation (for purposes of this subdivision only, the term "isomer" includes the optical, position, and geometric isomers):
(2-Methylaminopropyl)benzofuran (other name: MAPB)

Related

Endomorphin-1 in neighboring states

• Endomorphin-1 in District of Columbia Legal
• Endomorphin-1 in Kentucky Legal
• Endomorphin-1 in Maryland Legal
• Endomorphin-1 in North Carolina Legal
• Endomorphin-1 in Tennessee Legal
• Endomorphin-1 in West Virginia Legal

Endomorphin-1 in other states

Same framework in Virginia

• 4-HO-MET (Metocin) in Virginia Illegal
• 5-MAPB in Virginia Illegal
• Blue Lotus (Nymphaea caerulea) in Virginia Legal
• Amanita muscaria / Muscimol in Virginia Legal

Other compounds in Virginia

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