As of October 7, 2026, Endomorphin-1 is legal to sell at retail in New Hampshire. Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide. Controlling source: RSA 318-B:1 I-a (controlled drug analog; structure chapeau joined by AND).
Verified October 7, 2026 (manual) · confidence: confirmedEndomorphin-1 (Tyr-Pro-Trp-Phe-NH2) is not named or scheduled in New Hampshire. The state has a controlled-substance analogue statute whose similarity test is CONJUNCTIVE (chemical structure substantially similar to a scheduled substance AND a substantially similar CNS effect). The structure prong fails for a tetrapeptide, so the statute does not reach EM-1. Controlling instrument reviewed: RSA 318-B:1 I-a (controlled drug analog; structure chapeau joined by AND). Conclusion: no operative instrument reaches a structurally-dissimilar endogenous opioid peptide; status LEGAL at the state controlled-substances level. Residual risk: minimal. Federal floor still applies (Analogue Act human-consumption contingency + FD&C unapproved-new-drug).
RSA 318-B:1, VI-a(a): "'Controlled drug analog' means a substance ... the chemical structure of which is derivative of, or substantially similar to that of a controlled drug AND: (1) Which has been shown in laboratory studies to bind with and activate the same central nervous receptors ... responsible for the psychoactive effects of a certain controlled drug ...; or (2) ... which such person represents or intends to have similar psychoactive effects ..." (b) excludes approved-new-drug / investigational substances. [Structure chapeau joined by AND; targets psychoactive controlled drugs.]
Among New Hampshire's 3 neighbors, Maine, Massachusetts and Vermont are legal, the same posture as New Hampshire.
Open the interactive map · Every compound in New Hampshire
Not federally scheduled. Endomorphin-1 - not federally scheduled; endogenous opioid tetrapeptide, no CSA entry and no analogue-act structural hook Federal detail
3 instruments on file for this compound's framework in New Hampshire; 2 of 2 citations above are official sources. Each text carries its source and a fingerprint that changes when the law does.
619a7ad66c8cea56318-B:1 Definitions. -- VI-a. (a) "Controlled drug analog" means a substance, however constituted, the chemical structure of which is derivative of, or substantially similar to that of a controlled drug and: (1) Which has been shown in laboratory studies to bind with and activate the same central nervous receptors that are responsible for the psychoactive effects of a certain controlled drug or controlled drug class; or (2) With respect to a particular person, which such person represents or intends to have similar psychoactive effects on the central nervous system as a controlled drug. (b) "Controlled drug analog" shall not include: (1) A controlled drug; (2) Any substance for which there is an approved new drug application; (3) With respect to a particular person, any substance, if an exemption is in effect for investigational use for that person under 21 U.S.C. section 355, to the extent conduct with respect to the substance is pursuant to such an exemption; or (4) Any compound, mixture, or preparation that contains any controlled drug or controlled drug analog that is not for administration to a human being or animal, and that is packaged in such a form or concentration, or with adulterants or denaturants so that, as packaged, it does not present any significant potential for abuse. XXXI-a. "Substantially similar in chemical structure" means that the substance in question shares a common core structure with a controlled drug, meaning that the "backbone" of the molecule is the same, and has no more than 2 points of divergence (additions, deletions, or substitutions) from the controlled drug, which may consist of a single atom or a functional group or some combination thereof. Functional groups are further defined as alkyl, alkenyl, alkynyl, ring structures (either homocyclic or heterocyclic, with or without additional attached functional groups), organic halides, alkoxy, alcohol, ether, amine, aldehyde, ketone, carboxylic acid, ester, amide, nitrile, nitro, sulfide, thiene, thioester, or thiol.
3fbeffe6c9c96de9**RSA 318-B:1, VI-a(a) (controlled drug analog)** — "'Controlled drug analog' means a substance, however constituted, the chemical structure of which is derivative of, or substantially similar to that of a controlled drug and: (1) Which has been shown in laboratory studies to bind with and activate the same central nervous receptors that are responsible for the psychoactive effects of a certain controlled drug or controlled drug class; or (2) With respect to a particular person, which such person represents or intends to have similar psychoactive effects on the central nervous system as a controlled drug."
— RSA 318-B:1, VI-a(a), https://law.justia.com/codes/new-hampshire/title-xxx/chapter-318-b/section-318-b-1/ (MIRROR: Justia, 2025).
**RSA 318-B:1, XXXI-a ("substantially similar in chemical structure")** — "'Substantially similar in chemical structure' means that the substance in question shares a common core structure with a controlled drug, meaning that the 'backbone' of the molecule is the same, and has no more than 2 points of divergence (additions, deletions, or substitutions) from the controlled drug, which may consist of a single atom or a functional group or some combination thereof. Functional groups are further defined as alkyl, alkenyl, alkynyl, ring structures … amine …"
— RSA 318-B:1, XXXI-a. Same URL (MIRROR: Justia).
**RSA 318-B:1, XIII (hallucinogenic drugs, anchor)** — "'Hallucinogenic drugs' are psychodysleptic drugs … Exemplary of such drugs are mescaline, peyote, psilocybin and d-lysergic acid diethylamide."
— RSA 318-B:1, XIII. Same URL (MIRROR: Justia).7e1ece894e0c8416318-B:2, I. It shall be unlawful for any person to manufacture, possess, have under his control, sell, purchase, prescribe, administer, or transport or possess with intent to sell, dispense, or compound any controlled drug, or controlled drug analog, or any preparation containing a controlled drug, except as authorized in this chapter. 318-B:1, VI-a. (a) "Controlled drug analog" means a substance, however constituted, the chemical structure of which is derivative of, or substantially similar to that of a controlled drug and: (1) Which has been shown in laboratory studies to bind with and activate the same central nervous receptors that are responsible for the psychoactive effects of a certain controlled drug or controlled drug class; or (2) With respect to a particular person, which such person represents or intends to have similar psychoactive effects on the central nervous system as a controlled drug. (b) "Controlled drug analog" shall not include: (1) A controlled drug; (2) Any substance for which there is an approved new drug application; (3) With respect to a particular person, any substance, if an exemption is in effect for investigational use for that person under 21 U.S.C. section 355, to the extent conduct with respect to the substance is pursuant to such an exemption; or (4) Any compound, mixture, or preparation that contains any controlled drug or controlled drug analog that is not for administration to a human being or animal, and that is packaged in such a form or concentration, or with adulterants or denaturants so that, as packaged, it does not present any significant potential for abuse. 318-B:1, XXXI-a. "Substantially similar in chemical structure" means that the substance in question shares a common core structure with a controlled drug, meaning that the "backbone" of the molecule is the same, and has no more than 2 points of divergence (additions, deletions, or substitutions) from the controlled drug, which may consist of a single atom or a functional group or some combination thereof. Functional groups are further defined as alkyl, alkenyl, alkynyl, ring structures (either homocyclic or heterocyclic, with or without additional attached functional groups), organic halides, alkoxy, alcohol, ether, amine, aldehyde, ketone, carboxylic acid, ester, amide, nitrile, nitro, sulfide, thiene, thioester, or thiol.
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