As of July 18, 2026, Endomorphin-1 is legal to sell at retail in Michigan. Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide. Controlling source: MCL 333.7104(4) (controlled substance analogue; offense MCL 333.7402(2)(e)).
Verified July 18, 2026 · confidence: confirmedEndomorphin-1 (Tyr-Pro-Trp-Phe-NH2) is not named or scheduled in Michigan. The state has a controlled-substance analogue statute whose similarity test is CONJUNCTIVE (chemical structure substantially similar to a scheduled substance AND a substantially similar CNS effect). The structure prong fails for a tetrapeptide, so the statute does not reach EM-1. Controlling instrument reviewed: MCL 333.7104(4) (controlled substance analogue; offense MCL 333.7402(2)(e)). Conclusion: no operative instrument reaches a structurally-dissimilar endogenous opioid peptide; status LEGAL at the state controlled-substances level. Residual risk: low. Federal floor still applies (Analogue Act human-consumption contingency + FD&C unapproved-new-drug).
MCL 333.7104(4): "'Controlled substance analogue' means a substance the chemical structure of which is substantially similar to that of a controlled substance in schedule 1 or 2 AND that has a narcotic, stimulant, depressant, or hallucinogenic effect ... or, with respect to a particular individual, that the individual represents or intends ... Controlled substance analogue does not include ... (b) A substance for which there is an approved new drug application. (c) A substance with respect to which an exemption is in effect for investigational use ... (d) Any substance to the extent not intended for human consumption ..." [Conjunctive; plus human-consumption + approved/investigational-drug exclusions.]
Among Michigan's 3 neighbors, Indiana, Ohio and Wisconsin are legal, the same posture as Michigan.
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Not federally scheduled. Endomorphin-1 - not federally scheduled; endogenous opioid tetrapeptide, no CSA entry and no analogue-act structural hook Federal detail
2 instruments on file for this compound's framework in Michigan; 2 of 2 citations above are official sources. Each text carries its source and a fingerprint that changes when the law does.
d1c69c482ce4fb29**Analogue definition — MCL § 333.7104(4):** "'Controlled substance analogue' means a substance the chemical structure of which is substantially similar to that of a controlled substance in schedule 1 or 2 and that has a narcotic, stimulant, depressant, or hallucinogenic effect on the central nervous system substantially similar to or greater than [that] of a controlled substance included in schedule 1 or 2 or, with respect to a particular individual, that the individual represents or intends to have [such effect] … Controlled substance analogue does not include … (d) Any substance to the extent not intended for human consumption …"
— MCL § 333.7104(4), official Michigan Legislature: https://www.legislature.mi.gov/Laws/MCL?objectName=mcl-333-7104
**Schedule 1 — § 7212(1)(c):** hallucinogen list ("Bufotenine … Diethyltryptamine … Dimethyltryptamine (DMT) … Psilocybin … Psilocyn") with the catch-all "their salts, isomers, and salts of isomers"; § 7212(3) "'isomer' includes the optical, position, and geometric isomers." No structural tryptamine class. 4-HO-MET not named.
— MCL § 333.7212, official: https://www.legislature.mi.gov/Laws/MCL?objectName=mcl-333-7212e8c0162c5008c928333.27953 Definitions. Sec. 3. As used in this act: (f) "Industrial hemp" means any of the following: (i) A plant of the genus Cannabis, whether growing or not, with a THC concentration of 0.3% or less on a dry-weight basis. (ii) A part of a plant of the genus Cannabis, whether growing or not, with a THC concentration of 0.3% or less on a dry-weight basis. (iii) The seeds of a plant of the genus Cannabis with a THC concentration of 0.3% or less on a dry-weight basis. (iv) If it has a THC concentration of 0.3% or less on a dry-weight basis, a compound, manufacture, derivative, mixture, preparation, extract, cannabinoid, acid, salt, isomer, or salt of an isomer of any of the following: (A) A plant of the genus Cannabis. (B) A part of a plant of the genus Cannabis. (v) A product to which 1 of the following applies: (A) If the product is intended for human or animal consumption, the product, in the form in which it is intended for sale to a consumer, meets both of the following requirements: (I) Has a THC concentration of 0.3% or less on a dry-weight or per volume basis. (II) Contains a total amount of THC that is less than or equal to the limit established by the cannabis regulatory agency under section 8(1)(n). (B) If the product is not intended for human or animal consumption, the product meets both of the following requirements: (I) Contains a substance listed in subparagraph (i), (ii), (iii), or (iv). (II) Has a THC concentration of 0.3% or less on a dry-weight basis. (h) "Marihuana" means any of the following: (i) A plant of the genus Cannabis, whether growing or not. (ii) A part of a plant of the genus Cannabis, whether growing or not. (iii) The seeds of a plant of the genus Cannabis. (iv) Marihuana concentrate. (v) A compound, manufacture, salt, derivative, mixture, extract, acid, isomer, salt of an isomer, or preparation of any of the following: (A) A plant of the genus Cannabis. (B) A part of a plant of the genus Cannabis. (C) The seeds of a plant of the genus Cannabis. (D) Marihuana concentrate. (vi) A marihuana-infused product. (vii) A product with a THC concentration of more than 0.3% on a dry-weight or per volume basis in the form in which it is intended for sale to a consumer. (viii) A product that is intended for human or animal consumption and that contains, in the form in which it is intended for sale to a consumer, a total amount of THC that is greater than the limit established by the cannabis regulatory agency under section 8(1)(n). (i) Except for marihuana concentrate extracted from any of the following, "marihuana" does not include any of the following: (i) The mature stalks of a plant of the genus Cannabis. (ii) Fiber produced from the mature stalks of a plant of the genus Cannabis. (iii) Oil or cake made from the seeds of a plant of the genus Cannabis. (iv) A compound, manufacture, salt, derivative, mixture, or preparation of the mature stalks of a plant of the genus Cannabis. (v) Industrial hemp. (vi) An ingredient combined with marihuana to prepare topical or oral administrations, food, drink, or other products. (vii) A drug for which an application filed in accordance with 21 USC 355 is approved by the Food and Drug Administration. (aa) "THC" means any of the following: (i) Tetrahydrocannabinolic acid. (ii) Unless excluded by the cannabis regulatory agency under section 8(2)(c), a tetrahydrocannabinol, regardless of whether it is artificially or naturally derived. (iii) A tetrahydrocannabinol that is a structural, optical, or geometric isomer of a tetrahydrocannabinol described in subparagraph (ii).
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