As of July 18, 2026, Endomorphin-1 is legal to sell at retail in Indiana. Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide. Controlling source: IC 35-48-1-9.3 (controlled substance analog).
Verified July 18, 2026 · confidence: confirmedEndomorphin-1 (Tyr-Pro-Trp-Phe-NH2) is not named or scheduled in Indiana. The state has a controlled-substance analogue statute whose similarity test is CONJUNCTIVE (chemical structure substantially similar to a scheduled substance AND a substantially similar CNS effect). The structure prong fails for a tetrapeptide, so the statute does not reach EM-1. Controlling instrument reviewed: IC 35-48-1-9.3 (controlled substance analog). Conclusion: no operative instrument reaches a structurally-dissimilar endogenous opioid peptide; status LEGAL at the state controlled-substances level. Residual risk: minimal. Federal floor still applies (Analogue Act human-consumption contingency + FD&C unapproved-new-drug).
IC 35-48-1-9.3: "'Controlled substance analog' means a substance that, due to its chemical structure ... meets the following criteria: (1) The substance is substantially similar to a controlled substance classified under IC 35-48-2. (2) The substance has a narcotic, stimulant, depressant, or hallucinogenic effect ... substantially similar to or greater than" a controlled substance; (c) "'substantially similar' ... means ... a single difference in the structural formula that substitutes one (1) atom or functional group for another ..." [Conjunctive + single-atom structure test - fails for a peptide.]
Among Indiana's 4 neighbors, Illinois, Kentucky, Michigan and Ohio are legal, the same posture as Indiana.
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Not federally scheduled. Endomorphin-1 - not federally scheduled; endogenous opioid tetrapeptide, no CSA entry and no analogue-act structural hook Federal detail
2 instruments on file for this compound's framework in Indiana; 2 of 2 citations above are official sources. Each text carries its source and a fingerprint that changes when the law does.
b163f620c7c8ee20Sec. 321. 'Synthetic drug' means the following: (1) A substance containing one (1) or more of the following chemical compounds, including an analog of the compound: JWH-015 ((2-Methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone). JWH-018 (1-pentyl-3-(1-naphthoyl)indole). JWH-019 (1-hexyl-3-(naphthalen-1-oyl)indole). JWH-073 (naphthalen-1-yl-(1-butylindol-3-yl)methanone). JWH-081 (4-methoxynaphthalen-1-yl-(1-pentylindol-3-yl)methanone). JWH-122 (1-Pentyl-3-(4-methyl-1-naphthoyl)indole). JWH-200 ((1-(2-morpholin-4-ylethyl)indol-3-yl)-naphthalen-1-yl-methanone). JWH-250 (1-pentyl-3-(2-methoxyphenylacetyl)indole). JWH-251 (1-pentyl-3-(2-methylphenylacetyl)indole). JWH-398 (1-pentyl-3-(4-chloro-1-naphthoyl)indole). HU-210 ((6aR,10aR)-9-(Hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol). HU-211 ((6aS,10aS)-9-(Hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol). HU-308 ([(1R,2R,5R)-2-[2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl]-7,7-dimethyl-4-bicyclo[3.1.1]hept-3-enyl] methanol). HU-331 (3-hydroxy-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-2,5-cyclohexadiene-1,4-dione). CP 55,940 (2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl) cyclohexyl]-5-(2-methyloctan-2-yl)phenol). CP 47,497 (2-[(1R,3S)-3-hydroxycyclohexyl]-5-(2-methyloctan-2-yl)phenol) and its homologues, or 2-[(1R,3S)-3-hydroxycyclohexyl]-5-(2-methyloctan-2-yl) phenol), where side chain n=5, and homologues where side chain n=4, 6, or 7. WIN 55212-2 ((R)-(+)-[2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl) pyrrolo [1,2,3-de)-1,4-benzoxazin-6-yl]-1-napthalenylmethanone). RCS-4 ((4-methoxyphenyl) (1-pentyl-1H-indol-3-yl)methanone). RCS-8 (1-(1-(2-cyclohexylethyl)-1H-indol-3-yl)-2-(2-methoxyphenyl)ethanone). 4-Methylmethcathinone. Other name: mephedrone. 3,4-Methylenedioxymethcathinone. Other name: methylone. Fluoromethcathinone. 4-Methoxymethcathinone. Other name: methedrone. 4-Ethylmethcathinone (4-EMC). Methylenedioxypyrovalerone. Other name: MDPV. JWH-007, or 1-pentyl-2-methyl-3-(1-naphthoyl)indole. JWH-098, or 1-pentyl-2-methyl-3-(4-methoxy-1-naphthoyl)indole. JWH-164, or 1-pentyl-3-(7-methoxy-1-naphthoyl)indole. JWH-210, or 1-pentyl-3-(4-ethyl-1-naphthoyl)indole. JWH-201, or 1-pentyl-3-(4-methoxyphenylacetyl)indole. JWH-203, or 1-pentyl-3-(2-chlorophenylacetyl)indole. AM-694, or 1-(5-fluoropentyl)-3-(2-iodobenzoyl)indole. CP 50,556-1, or [(6S,6aR,9R,10aR)-9-hydroxy-6-methyl-3-[(2R)-5-phenylpentan-2-yl]oxy-5,6,6a,7,8,9,10,10a-octahydrophenanthridin-1-yl] acetate. Dimethylheptylpyran, or DMHP. 4-Methyl-alpha-pyrrolidinobutiophenone, or MPBP. 6-APB [6-(2-aminopropyl)benzofuran]. 7-hydroxymitragynine. alpha-PPP [alpha-pyrrolidinopropiophenone]. alpha-PVP (desmethylpyrovalerone). AM-251. AM-1241. AM-2201. AM-2233. Buphedrone (alpha-methylamino-butyrophenone (MABP)). Butylone. CP-47,497-C7. CP-47,497-C8. Desoxypipradol. Ethylone. Eutylone. Flephedrone. JWH-011. JWH-020. JWH-022. JWH-030. JWH-182. JWH-302. MDAI [5,6-methylenedioxy-2-aminoindane]. Mitragynine. Naphyrone. Pentedrone. Pentylone. A796,260 [1-(2-morpholin-4-ylethyl)-1H-indol-3-yl]-(2,2,3,3-tetramethylcyclopropyl)methanone]. AB-001[(1s,3s)-admantan-1-yl) (1-pentyl-1H-indol-3-yl)methanone] or [1-Pentyl-3-(1-adamantoyl)indole]. AM-356 [Methanandamide]. AM 1248 [1-[(1-methyl-2-piperidinyl) methyl]-1H-indol-3-yl] tricyclo[3.3.1.13,7] dec-1-yl-methanone]or [(1-[(N-methylpiperindin-2-yl) Methyl]-3-(Adamant-1-oyl)indole)]. AM 2233 Azepane isomer [(2-iodophenyl) (1-(1-methylazepan-3-yl)-1H-indol-3-yl)methanone]. CB-13 [1-Naphthalenyl [4-(pentyoxy)-1-naphthalenyl]methanone]. UR-144 [(1-pentyl-1H-indol-3-yl) (2,2,3,3-tetramethylcyclopropyl)-methanone]. URB 597 [(3'-(aminocarbonyl) [1,1'-biphenyl]-3-yl)-cyclohexylcarbamate]. URB602 [[1,1'-biphenyl]-3-yl-carbamic acid, cyclohexyl ester]. URB 754 [6-methyl-2-[(4-methylphenyl) amino]-1-benzoxazin-4-one]. XLR-11 or 5-fluoro UR-144 (1-(5-fluoropentyl)-1H-indol-3-yl) (2,2,3,3-tetramethylcyclopropyl)methanone]. AKB48 (Other names include: N-Adamantyl-1-pentyl-1H-Indazole-3-carboxamide; 1-pentyl-N-tricyclo[3.3.1.13.7]dec-1-yl-1H-indazole-3-carboxamide). 25I-NBOMe (Other names include: 4-Iodo-2,5-dimethoxy-N-[(2-methoxyphenyl)methyl]-benzeneethanamine); 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl) methyl]ethanamine). 2C-C-NBOMe (Other names include: 25C-NBOMe; 2-(4-chloro-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl) methyl]ethanamine; 2,5-Dimethoxy-4-chloro-N-(2-methoxybenzyl) phenethylamine). 2NE-1 (Other names include: 1-Pentyl-3-(1-adamantylamido)indole). STS-135 (Other names include: N-Adamantyl-1-fluoropentylindole-3-carboxamide (1-5-fluoropentyl)-N-tricyclo[3.3.1.13.7]dec-1-yl-1H-indole-3-carboxamide). PB-22 (Other names include: 1-Pentyl-8-quinolinlyl ester-1H-indole-2-carboxylic acid). 5-Fluoro-PB-22 (Other names include: 1-(5-Fluropentyl)-8-quinolinyl ester1H-indole-3-carboxylic acid). Benocyclidine (Other names include: BCP, BTCP, and Benzothiophenylcyclohexylpiperidine). 25B-NBOMe (Other names include: 2C-B-NBOMe and 4-Bromo-2,5-dimenthoxy-N-[(2-Methozyphenyl)methyl] benzeneethanamine). APB (Other names include: (2-Aminopropyl) Benzofuran). AB-PINACA (N-(1-Amino-3-methyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide. AB-FUBINACA (N-(1-Amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide). ADB-PINACA (N-(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-1-pentyl-1H-indaole-3-carboxamide). Fluoro ADBICA (N-(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-(fluoropentyl)-1H-indole-3-carboxamide). APDB (Other names include: -EMA, -Desoxy-MDA, and (2-Aminopropyl)-2,3-dihydrobenzofuran). THJ-2201 (Other names include: AM2201 indazole analog, Fluoropentyl-JWH-018 indazole, and 5-Fluoro-THJ-018). AM 2201 benzimidazole analog (Other names include: FUBIMINA, FTHJ, and (1-(5-fluoropentyl)-1H-benzo[d]imidazol-2-yl)(naphthalene-1-yl)methanone). MN-25 (Other names include: 7-methoxy-1-[2-(4-morpholinyl)ethyl]-N-[1S, 2S, 4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-indole-3-carboxamide and UR-12). FUB-PB-22 (Other names include: Quinolin-8-yl-1-(4-fluorobenzyl)-1H-indole-3-carboxylate). FUD-PB-22 (Other names include: Naphthalen-1-yl-1-(4-fluorobenzyl)-1H-indole-3-carboxylate). 5-Fluoro-AB-PINACA (Other names include: AB-PINACA 5-fluoro analog and N-(1-amino-3-methyl1-oxobutan-2-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxaminde). 4-MePPP (Other names include: 4-methyl-alpha-pyrrolidinopropiophenone). alpha-PBP (Other names include: Alpha-pyrrolidinobutiophenone). AB-CHMINACA (Other names include: (N-[1-(aminocarbonyl)-2-methylpropyl]-1-(cyclohexylmethyl)-1H-indazole-3-carboxamide). Mexedrone (3-methoxy-2-(methylamino)-1-(p-tolyl)propan-1-one). MT-45, (1-cyclohexyl-4-(1,2-diphenylethyl)piperazine). methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate [5F-ADB; 5F-MDMB-PINACA]. methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3-methylbutanoate [5F-AMB]. N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide [ADB-FUBINACA]. N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide [5F-APINACA, 5F-AKB48]. methyl 2-(1-(cyclohexylmethyl)-1H-indole-3-carboxamido)-3,3-dimethylbutanoate [MDMB-CHMICA, MMB-CHMINACA]. methyl 2-(1-(4-fluorobenzyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate [MDMB-FUBINACA]. N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-1H-indazole-3-carboxamide [MAB-CHMINACA and ADB-CHMINACA]. Methyl 2-(1-(4-fluorobenzyl)-1H-indazole-3-carboxamido)-3-methylbutanoate [FUB-AMB, MMB-FUBINACA, AMB-FUBINACA]. 3,4-dichloro-N-[(1dimethylamino)cyclohexylmethyl]benzamide) [AH7921]. Naphthalen-1-yl 1-(5-fluoropentyl)-1H-indole-3-carboxylate (trivial name: NM2201; CBL2201) 1-(4-cyanobutyl)-N-(2-phenylpropan-2-yl)-1H-indazole-3-carboxamide (trivial name: 4-CN-CUMYL-BUTINACA; 4-cyano-CUMYL-BUTINACA; 4-CN-CUMYL BINACA; CUMYL-4CN-BINACA; SGT-78). methyl 2-(1-(cyclohexylmethyl)-1H-indole-3-carboxamido)-3-methylbutanoate (trivial names: MMB-CHMICA, AMB-CHMICA). 1-(5-fluoropentyl)-N-(2-phenylpropan-2-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide (trivial name: 5F-CUMYL-P7AICA). N-1-(1,3-benzodioxol-5-yl)-2-(ethylamino)-1-pentanone (N-ethylpentylone, ephylone). Synthetic cathinone, 1-(1,3-benzodioxol-5-yl)-2-(ethylamino)-pentan-1-one (N-ethylpentylone, ephylone) and its optical, positional, and geometric isomers, salts, and salts of isomers. ethyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate (trivial name: 5F-EDMB-PINACA). methyl 2-(1-(5-fluoropentyl)-1H-indole-3-carboxamido)-3,3-dimethylbutanoate (trivial name: 5F-MDMB-PICA). N-(adamantan-1-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide (trivial names: FUB-AKB48; FUB-APINACA; AKB48 N-(4-FLUOROBENZYL)). 1-(5-fluoropentyl)-N-(2-phenylpropan-2-yl)-1H-indazole-3-carboxamide (trivial names: 5F-CUMYL-PINACA; SGT-25). (1-(4-fluorobenzyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl) methanone (trivial name: FUB-144). 4F-MDMB-BINACA. N-ethylhexedrone (2-(ethylamino)-1-phenylhexan-1-one). alpha-pyrrolidinohexanophenone (1-phenyl-2-(pyrrolidin-1-yl)hexan-1-one. alpha-pyrrolidinohexiophenone; trivial name: a-PHP. 4'-methyl-alpha-pyrrolidinohexiophenone (1-(4-methylphenyl)-2-(pyrrolidin-1-yl)hexan-1-one. 4-methyl-alphaethylaminopentiophenone (2-(ethylamino)-1-(4-methylphenyl)pentan-1-one; trivial name: 4-MEAP. 4'-methyl-alphapyrrolidinohexanophenone; trivial name: MPHP. alphapyrrolidinoheptaphenone (1-phenyl-2-(pyrrolidin-1-yl)heptan-1-one; trivial name: PV8. 4'-chloro-alphapyrrolidinovalerophenone (1-(4-chlorophenyl)-2-(pyrrolidin-1-yl)pentan-1-one. 4'-chloro-alphapyrrolidinopentiophenone; trivial name: 4-chloro-a-PVP. MDMB-4en-PINACA; Methyl 3,3-dimethyl-2-(1-(pent-4-en-1-yl)-1H[1]indazole-3-carboxamido)butanoate. 4F-MDMB-BICA; 4-fluoro MDMB-BICA; 4F-MDMB-BUTICA; Methyl 2-[[1-(4-fluorobutyl)indole-3-carbonyl]amino]-3,3-dimethyl-butanoate. Other name: 4-fluoro MDMB-BICA.
c72ced5bb263abbb**§ 35-48-2-4(d)** "Hallucinogenic substances. Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of the following hallucinogenic, psychedelic, or psychogenic substances, their salts, isomers, and salts of isomers whenever the existence of these salts, isomers, and salts of isomers is possible within the specific chemical designation (for purposes of this subsection only, the term 'isomer' includes the optical, position, and geometric isomers): … **(48) 4-Hydroxy-MET (4-Hydroxy-N-methyl-N-ethyltryptamine)** …" — Ind. Code § 35-48-2-4(d)(48); text via labeled Justia mirror (2023 Indiana Code): https://law.justia.com/codes/indiana/title-35/article-48/chapter-2/section-35-48-2-4/ (amendment history confirms P.L.48-2023, SEC.4 as the latest)
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