As of July 18, 2026, Endomorphin-1 is legal to sell at retail in Missouri. Unscheduled - legal as research-use-only; no operative instrument reaches a structurally-dissimilar opioid peptide. Controlling source: RSMo 195.010(7) (controlled substance analogue).
Verified July 18, 2026 · confidence: confirmedEndomorphin-1 (Tyr-Pro-Trp-Phe-NH2) is not named or scheduled in Missouri. The state has a controlled-substance analogue statute whose similarity test is CONJUNCTIVE (chemical structure substantially similar to a scheduled substance AND a substantially similar CNS effect). The structure prong fails for a tetrapeptide, so the statute does not reach EM-1. Controlling instrument reviewed: RSMo 195.010(7) (controlled substance analogue). Conclusion: no operative instrument reaches a structurally-dissimilar endogenous opioid peptide; status LEGAL at the state controlled-substances level. Residual risk: minimal. Federal floor still applies (Analogue Act human-consumption contingency + FD&C unapproved-new-drug).
RSMo 195.010(7): "'Controlled substance analogue' ... the chemical structure of which is substantially similar to the chemical structure of a controlled substance in Schedule I or II AND ... (a) which has a stimulant, depressant, or hallucinogenic effect ... substantially similar ...; or (b) ... which that individual represents or intends ..." [Conjunctive - structure prong fails.]
Among Missouri's 8 neighbors, Arkansas, Illinois, Iowa, Kansas, Kentucky, Nebraska, Oklahoma and Tennessee are legal, the same posture as Missouri.
Open the interactive map · Every compound in Missouri
Not federally scheduled. Endomorphin-1 - not federally scheduled; endogenous opioid tetrapeptide, no CSA entry and no analogue-act structural hook Federal detail
2 instruments on file for this compound's framework in Missouri; 2 of 2 citations above are official sources. Each text carries its source and a fingerprint that changes when the law does.
40421b2949322e51EXECUTIVE ORDER 24-10 WHEREAS, there are currently no safety standards, packaging requirements, or other regulations related to the safety of consuming unregulated psychoactive cannabis products in Missouri; and WHEREAS, unregulated psychoactive cannabis products include delta-8 tetrahydrocannabinol (THC), delta-10 THC, hexahydrocannabinol (HHC), tetrahydrocannabinol (THC-O), tetrahydrocannabiphoral (THCP), tetrahydrocannabivarin (THCV), and other similar compounds; and WHEREAS, numerous Missourians have been negatively impacted by the consumption of foods with unregulated psychoactive cannabis products added to them; and WHEREAS, Missouri children, and children across the nation, have been hospitalized due to consuming unregulated psychoactive cannabis products; and WHEREAS, additional actions must be taken to protect consumers, including children, from the sale of foods that include unregulated psychoactive cannabis products; and WHEREAS, the Missouri Department of Health and Senior Services (DHSS) is tasked with ensuring the protection of the public when it comes to food under Chapter 196, RSMo; and WHEREAS, the DHSS is tasked with promulgating regulations that conform, insofar as practicable, with those promulgated under federal acts under Section 196.045, RSMo; and WHEREAS, state law currently prohibits the sale of foods that are adulterated or misbranded under Section 196.015, RSMo; and WHEREAS, the DHSS has promulgated rules and a Food Code under Section 196.045, RSMo, which align with the United States Food and Drug Administration (FDA); and WHEREAS, the FDA and the Missouri Food Code require that all food come from approved sources; and WHEREAS, the FDA and the Missouri Food Code require that food that is not from an approved source shall be discarded; and WHEREAS, the FDA and the Missouri Food Code require that food additives must be approved food additives or come from approved food sources; and WHEREAS, there is no unregulated psychoactive cannabis product that has been approved by the FDA as a food additive; and WHEREAS, the FDA has stated that food additives must receive premarket approval, and the failure to obtain premarket approval causes the food to be marked as adulterated by the FDA; and WHEREAS, Section 311.660, RSMo, provides the Missouri Division of Alcohol and Tobacco Control within the Missouri Department of Public Safety with the statutory authority to enforce Missouri's alcohol and tobacco laws and regulations to ensure a safe environment for citizens of Missouri; and WHEREAS, Missouri regulations currently prohibit the sale of controlled substances on liquor-licensed premises, but are silent on the sale of other unregulated psychoactive cannabis products. NOW, THEREFORE, I, MICHAEL L. PARSON, GOVERNOR OF THE STATE OF MISSOURI, by virtue and authority vested in me by the Constitution and laws of the State of Missouri, do hereby order the DHSS, beginning on September 1, 2024, to designate foods containing unregulated psychoactive cannabis products as foods that come from an unapproved food source or as foods that contain an unapproved food additive that comes from an unapproved food source as set forth in the 2022 FDA Food Code and the 2013 Missouri Food Code, or revisions of said codes. Additionally, the DHSS is to find foods that contain unregulated psychoactive cannabis products are deleterious, poisonous, and adulterated under Sections 196.070, RSMo, and 196.085, RSMo, and to take the necessary steps in accordance with statute and regulation to embargo and condemn any food containing unregulated psychoactive cannabis products. These provisions do not apply to products under the control or purview of the Division of Cannabis Regulation under Article XIV of the Missouri Constitution as long as all psychoactive cannabinoids in those products are sourced from establishments licensed under Article XIV of the Missouri Constitution. I further direct the DHSS to produce and distribute information regarding how the DHSS will regulate products consistent with this Executive Order. I further direct the Missouri Division of Alcohol and Tobacco Control to amend its regulations such that unregulated psychoactive cannabis products are prohibited from being sold on the premises of a liquor-licensed facility. IN WITNESS WHEREOF, I have hereunto set my hand and caused to be affixed the Great Seal of the State of Missouri, in the City of Jefferson, on this 1st day of August, 2024. MICHAEL L. PARSON, GOVERNOR ATTEST: JOHN R. ASHCROFT, SECRETARY OF STATE
e236a8b51b88a4b8**RSMo 195.017.2(5)** — "Any material, compound, mixture or preparation which contains any quantity of the following hallucinogenic substances, their salts, isomers and salts of isomers, unless specifically excepted … (a) Alpha-ethyltryptamine; … (ll) Psilocybin; (mm) Psilocyn; …" — RSMo 195.017, https://revisor.mo.gov/main/OneSection.aspx?section=195.017 (OFFICIAL — Missouri Revisor). 4-HO-MET is not listed. **RSMo 195.010(7) (analogue definition)** — "'Controlled substance analogue', a substance the chemical structure of which is substantially similar to the chemical structure of a controlled substance in Schedule I or II and: (a) Which has a stimulant, depressant, or hallucinogenic effect … substantially similar … or (b) … which that individual represents or intends to have [such effect] … The term does not include … any substance to the extent not intended for human consumption …" — RSMo 195.010(7), https://revisor.mo.gov/main/OneSection.aspx?section=195.010 (OFFICIAL). **RSMo 579.068 (the only offense that deploys "analogue" — fentanyl/carfentanil only)** — "A person commits the offense of trafficking drugs in the second degree if … such person knowingly possesses or has under his or her control … (9) More than ten milligrams of fentanyl or carfentanil, or any derivative thereof … or their optical isomers or analogues." — RSMo 579.068, https://revisor.mo.gov/main/OneSection.aspx?section=579.068 (OFFICIAL).
Compound Laws, published by Compound Analytics, reports the record: statutes verbatim, official citations, enforcement facts and verification dates. Nothing here is legal advice and nothing here describes how to get around a law. A jurisdiction with no verified row is reported as not yet verified, never as legal. Found an error? Corrections policy.
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